Tomi Pastinen

Home / Investigators  / Tomi Pastinen

Tomi Pastinen

Director, Center for Pediatric Genomic Medicine, Children’s Mercy Kansas City
Adjunct Professor, Department of Human Genetics

Email: tpastinen@cmh.edu

Children’s Mercy Hospital
2401 Gillham Rd
Kansas City MO 64108

Dr. Pastinen has been the Director of the Center for Pediatric Genomic Medicine (CPGM) since 2017. Dr. Pastinen joined Children’s Mercy from McGill University. He held the Canada Research Chair from 2007 to 2017 and has a significant track record of academic achievement. He has authored over 120 peer-reviewed publications, including papers in top-tier journals Cell and Nature Genetics. Prior to joining Children’s Mercy, he led the epigenome mapping center at McGill as part of the International Human Epigenome Consortium, which provides maps of genome function to the global research community. Dr. Pastinen is leading Genomic Answers for Kids, a foundational initiative for future genomic research at Children’s Mercy that aims to learn from 30,000 children with genetic conditions.

Recent Publications

  • Vehik, K, Boulware, D, Killian, M, Rewers, M, McIndoe, R, Toppari, J et al.. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022;45 (10):2342-2349. doi: 10.2337/dc22-0828. PubMed PMID:36150054 .
  • Krischer, JP, Liu, X, Lernmark, Å, Hagopian, WA, Rewers, MJ, She, JX et al.. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022;45 (10):2271-2281. doi: 10.2337/dc21-2612. PubMed PMID:36150053 .
  • Fraley, ER, Khanal, S, Pierce, SH, LeMaster, CA, McLennan, R, Pastinen, T et al.. Effects of Prior Infection with SARS-CoV-2 on B Cell Receptor Repertoire Response during Vaccination. Vaccines (Basel). 2022;10 (9):. doi: 10.3390/vaccines10091477. PubMed PMID:36146555 .
  • Bonkowsky, JL, Pastinen, T, White, P. The post-diagnostics world: charting a path for pediatric genomic medicine in the twenty-first century. Pediatr Res. 2022; :. doi: 10.1038/s41390-022-02144-2. PubMed PMID:35690684 PubMed Central PMC9187847.
  • Shao, X, Le Stunff, C, Cheung, W, Kwan, T, Lathrop, M, Pastinen, T et al.. Differentially methylated CpGs in response to growth hormone administration in children with idiopathic short stature. Clin Epigenetics. 2022;14 (1):65. doi: 10.1186/s13148-022-01281-z. PubMed PMID:35585611 PubMed Central PMC9118695.
  • McQuerry, JA, Mclaird, M, Hartin, SN, Means, JC, Johnston, J, Pastinen, T et al.. Massively parallel identification of functionally consequential noncoding genetic variants in undiagnosed rare disease patients. Sci Rep. 2022;12 (1):7576. doi: 10.1038/s41598-022-11589-8. PubMed PMID:35534523 PubMed Central PMC9085742.
  • Oussalah, A, Siblini, Y, Hergalant, S, Chéry, C, Rouyer, P, Cavicchi, C et al.. Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12. Clin Epigenetics. 2022;14 (1):52. doi: 10.1186/s13148-022-01271-1. PubMed PMID:35440018 PubMed Central PMC9020039.
  • Hård Af Segerstad, EM, Liu, X, Uusitalo, U, Agardh, D, Andrén Aronsson, C, TEDDY Study Group et al.. Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2022;116 (2):394-403. doi: 10.1093/ajcn/nqac086. PubMed PMID:35394004 PubMed Central PMC9348971.
  • Cohen, ASA, Farrow, EG, Abdelmoity, AT, Alaimo, JT, Amudhavalli, SM, Anderson, JT et al.. Genomic answers for children: Dynamic analyses of >1000 pediatric rare disease genomes. Genet Med. 2022;24 (6):1336-1348. doi: 10.1016/j.gim.2022.02.007. PubMed PMID:35305867 .
  • Törn, C, Liu, X, Onengut-Gumuscu, S, Counts, KM, Moreno, JL, Remedios, CL et al.. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022;12 (1):4516. doi: 10.1038/s41598-022-08058-7. PubMed PMID:35296692 PubMed Central PMC8927592.
Search PubMed