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Tomi Pastinen

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Tomi Pastinen

Director, Center for Pediatric Genomic Medicine, Children’s Mercy Kansas City
Adjunct Professor, Department of Human Genetics

Email: tpastinen@cmh.edu

Children’s Mercy Hospital
2401 Gillham Rd
Kansas City MO 64108

Dr. Pastinen has been the Director of the Center for Pediatric Genomic Medicine (CPGM) since 2017. Dr. Pastinen joined Children’s Mercy from McGill University. He held the Canada Research Chair from 2007 to 2017 and has a significant track record of academic achievement. He has authored over 120 peer-reviewed publications, including papers in top-tier journals Cell and Nature Genetics. Prior to joining Children’s Mercy, he led the epigenome mapping center at McGill as part of the International Human Epigenome Consortium, which provides maps of genome function to the global research community. Dr. Pastinen is leading Genomic Answers for Kids, a foundational initiative for future genomic research at Children’s Mercy that aims to learn from 30,000 children with genetic conditions.

Recent Publications

  • Groza, C, Kwan, T, Soranzo, N, Pastinen, T, Bourque, G. Personalized and graph genomes reveal missing signal in epigenomic data. Genome Biol. 2020;21 (1):124. doi: 10.1186/s13059-020-02038-8. PubMed PMID:32450900 PubMed Central PMC7249353.
  • Zhao, K, Oualkacha, K, Lakhal-Chaieb, L, Labbe, A, Klein, K, Ciampi, A et al.. A novel statistical method for modeling covariate effects in bisulfite sequencing derived measures of DNA methylation. Biometrics. 2020; :. doi: 10.1111/biom.13307. PubMed PMID:32438470 .
  • Madore, AM, Pain, L, Boucher-Lafleur, AM, Morin, A, Meloche, J, Simon, MM et al.. Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells. J Genet Genomics. 2020;47 (3):171-174. doi: 10.1016/j.jgg.2020.03.002. PubMed PMID:32312674 .
  • Vijay, J, Gauthier, MF, Biswell, RL, Louiselle, DA, Johnston, JJ, Cheung, WA et al.. Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat Metab. 2020;2 (1):97-109. doi: 10.1038/s42255-019-0152-6. PubMed PMID:32066997 PubMed Central PMC7025882.
  • Battaglia, M, Ahmed, S, Anderson, MS, Atkinson, MA, Becker, D, Bingley, PJ et al.. Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care. 2020;43 (1):5-12. doi: 10.2337/dc19-0880. PubMed PMID:31753960 PubMed Central PMC6925574.
  • Chan, D, Shao, X, Dumargne, MC, Aarabi, M, Simon, MM, Kwan, T et al.. Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism. Environ. Health Perspect. 2019;127 (8):87002. doi: 10.1289/EHP4812. PubMed PMID:31393794 PubMed Central PMC6792365.
  • Ritari, J, Hyvärinen, K, Koskela, S, Niittyvuopio, R, Nihtinen, A, Salmenniemi, U et al.. Computational Analysis of HLA-presentation of Non-synonymous Recipient Mismatches Indicates Effect on the Risk of Chronic Graft-vs.-Host Disease After Allogeneic HSCT. Front Immunol. 2019;10 :1625. doi: 10.3389/fimmu.2019.01625. PubMed PMID:31379830 PubMed Central PMC6646417.
  • Shao, X, Hudson, M, Colmegna, I, Greenwood, CMT, Fritzler, MJ, Awadalla, P et al.. Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing. Clin Epigenetics. 2019;11 (1):110. doi: 10.1186/s13148-019-0699-9. PubMed PMID:31366403 PubMed Central PMC6668183.
  • Lalonde, S, Codina-Fauteux, VA, de Bellefon, SM, Leblanc, F, Beaudoin, M, Simon, MM et al.. Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene. Genome Biol. 2019;20 (1):133. doi: 10.1186/s13059-019-1749-5. PubMed PMID:31287004 PubMed Central PMC6613242.
  • Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A et al.. Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat. Genet. 2019;51 (7):1192-1193. doi: 10.1038/s41588-019-0449-0. PubMed PMID:31160810 .
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