Loading...

Tomi Pastinen

Home / Investigators  / Tomi Pastinen

Tomi Pastinen

Director, Center for Pediatric Genomic Medicine, Children’s Mercy Kansas City
Adjunct Professor, Department of Human Genetics

Email: tpastinen@cmh.edu

Children’s Mercy Hospital
2401 Gillham Rd
Kansas City MO 64108

Dr. Pastinen has been the Director of the Center for Pediatric Genomic Medicine (CPGM) since 2017. Dr. Pastinen joined Children’s Mercy from McGill University. He held the Canada Research Chair from 2007 to 2017 and has a significant track record of academic achievement. He has authored over 120 peer-reviewed publications, including papers in top-tier journals Cell and Nature Genetics. Prior to joining Children’s Mercy, he led the epigenome mapping center at McGill as part of the International Human Epigenome Consortium, which provides maps of genome function to the global research community. Dr. Pastinen is leading Genomic Answers for Kids, a foundational initiative for future genomic research at Children’s Mercy that aims to learn from 30,000 children with genetic conditions.

Recent Publications

  • Zeng, Y, Zhao, K, Oros Klein, K, Shao, X, Fritzler, MJ, Hudson, M et al.. Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals. Genes (Basel). 2021;12 (9):. doi: 10.3390/genes12091349. PubMed PMID:34573331 PubMed Central PMC8472734.
  • Fraley, E, LeMaster, C, Khanal, S, Banerjee, D, Pastinen, T, Grundberg, E et al.. Prior infection and age impacts antibody persistence after SARS-CoV-2 mRNA vaccine. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab850. PubMed PMID:34551091 PubMed Central PMC8522412.
  • Škorić-Milosavljević, D, Lahrouchi, N, Bosada, FM, Dombrowsky, G, Williams, SG, Lesurf, R et al.. Correction to: Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. Genet Med. 2021;23 (10):2013. doi: 10.1038/s41436-021-01279-7. PubMed PMID:34522030 PubMed Central PMC8486656.
  • Winkley, K, Banerjee, D, Bradley, T, Koseva, B, Cheung, WA, Selvarangan, R et al.. Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range. Sci Rep. 2021;11 (1):15927. doi: 10.1038/s41598-021-95532-3. PubMed PMID:34354210 PubMed Central PMC8342554.
  • Berrios, C, Hurley, EA, Willig, L, Thiffault, I, Saunders, C, Pastinen, T et al.. Challenges in genetic testing: clinician variant interpretation processes and the impact on clinical care. Genet Med. 2021;23 (12):2289-2299. doi: 10.1038/s41436-021-01267-x. PubMed PMID:34257423 .
  • Škorić-Milosavljević, D, Lahrouchi, N, Bosada, FM, Dombrowsky, G, Williams, SG, Lesurf, R et al.. Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. Genet Med. 2021;23 (10):1952-1960. doi: 10.1038/s41436-021-01212-y. PubMed PMID:34113005 PubMed Central PMC8486653.
  • Watt, S, Vasquez, L, Walter, K, Mann, AL, Kundu, K, Chen, L et al.. Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease. Nat Commun. 2021;12 (1):2298. doi: 10.1038/s41467-021-22548-8. PubMed PMID:33863903 PubMed Central PMC8052402.
  • Winkley, K, Koseva, B, Banerjee, D, Cheung, W, Selvarangan, R, Pastinen, T et al.. High-resolution epigenome analysis in nasal samples derived from children with respiratory viral infections reveals striking changes upon SARS-CoV-2 infection. medRxiv. 2021; :. doi: 10.1101/2021.03.09.21253155. PubMed PMID:33758880 PubMed Central PMC7987039.
  • Bradley, T, Grundberg, E, Selvarangan, R, LeMaster, C, Fraley, E, Banerjee, D et al.. Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine. N Engl J Med. 2021;384 (20):1959-1961. doi: 10.1056/NEJMc2102051. PubMed PMID:33755375 PubMed Central PMC8008753.
  • Lutz, PE, Chay, MA, Pacis, A, Chen, GG, Aouabed, Z, Maffioletti, E et al.. Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation. Nat Commun. 2021;12 (1):1132. doi: 10.1038/s41467-021-21365-3. PubMed PMID:33602921 PubMed Central PMC7892573.
Search PubMed