Tomi Pastinen

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Tomi Pastinen

Director, Center for Pediatric Genomic Medicine, Children’s Mercy Kansas City
Adjunct Professor, Department of Human Genetics

Email: tpastinen@cmh.edu

Children’s Mercy Hospital
2401 Gillham Rd
Kansas City MO 64108

Dr. Pastinen has been the Director of the Center for Pediatric Genomic Medicine (CPGM) since 2017. Dr. Pastinen joined Children’s Mercy from McGill University. He held the Canada Research Chair from 2007 to 2017 and has a significant track record of academic achievement. He has authored over 120 peer-reviewed publications, including papers in top-tier journals Cell and Nature Genetics. Prior to joining Children’s Mercy, he led the epigenome mapping center at McGill as part of the International Human Epigenome Consortium, which provides maps of genome function to the global research community. Dr. Pastinen is leading Genomic Answers for Kids, a foundational initiative for future genomic research at Children’s Mercy that aims to learn from 30,000 children with genetic conditions.

Recent Publications

  • Cummings, L, Tucker, M, Gibson, M, Myers, A, Pastinen, T, Johnston, J et al.. Rare Genetic Variants in Immune Genes and Neonatal Herpes Simplex Viral Infections. Pediatrics. 2021;147 (1):. doi: 10.1542/peds.2020-0687. PubMed PMID:33386334 .
  • Cao, M, Shao, X, Chan, P, Cheung, W, Kwan, T, Pastinen, T et al.. High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations. Clin Epigenetics. 2020;12 (1):192. doi: 10.1186/s13148-020-00988-1. PubMed PMID:33317634 PubMed Central PMC7735420.
  • Bélanger, É, Madore, AM, Boucher-Lafleur, AM, Simon, MM, Kwan, T, Pastinen, T et al.. Eosinophil microRNAs Play a Regulatory Role in Allergic Diseases Included in the Atopic March. Int J Mol Sci. 2020;21 (23):. doi: 10.3390/ijms21239011. PubMed PMID:33260893 PubMed Central PMC7730597.
  • Dyke, SOM, Ennis, CA, Joly, Y, Walter, J, Siebert, R, Pastinen, T et al.. Communicating science: epigenetics in the spotlight. Environ Epigenet. 2020;6 (1):dvaa015. doi: 10.1093/eep/dvaa015. PubMed PMID:33240528 PubMed Central PMC7673471.
  • Chen, L, Yang, R, Kwan, T, Tang, C, Watt, S, Zhang, Y et al.. Paired rRNA-depleted and polyA-selected RNA sequencing data and supporting multi-omics data from human T cells. Sci Data. 2020;7 (1):376. doi: 10.1038/s41597-020-00719-4. PubMed PMID:33168820 PubMed Central PMC7652884.
  • Groza, C, Kwan, T, Soranzo, N, Pastinen, T, Bourque, G. Personalized and graph genomes reveal missing signal in epigenomic data. Genome Biol. 2020;21 (1):124. doi: 10.1186/s13059-020-02038-8. PubMed PMID:32450900 PubMed Central PMC7249353.
  • Zhao, K, Oualkacha, K, Lakhal-Chaieb, L, Labbe, A, Klein, K, Ciampi, A et al.. A novel statistical method for modeling covariate effects in bisulfite sequencing derived measures of DNA methylation. Biometrics. 2020; :. doi: 10.1111/biom.13307. PubMed PMID:32438470 .
  • Madore, AM, Pain, L, Boucher-Lafleur, AM, Morin, A, Meloche, J, Simon, MM et al.. Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells. J Genet Genomics. 2020;47 (3):171-174. doi: 10.1016/j.jgg.2020.03.002. PubMed PMID:32312674 .
  • Vijay, J, Gauthier, MF, Biswell, RL, Louiselle, DA, Johnston, JJ, Cheung, WA et al.. Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat Metab. 2020;2 (1):97-109. doi: 10.1038/s42255-019-0152-6. PubMed PMID:32066997 PubMed Central PMC7025882.
  • Battaglia, M, Ahmed, S, Anderson, MS, Atkinson, MA, Becker, D, Bingley, PJ et al.. Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care. 2020;43 (1):5-12. doi: 10.2337/dc19-0880. PubMed PMID:31753960 PubMed Central PMC6925574.
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