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Anavaj Sakuntabhai

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Anavaj Sakuntabhai

Head, Functional Genetics of Infectious Diseases, Pasteur Institute

Email: anavaj@pasteur.fr
Phone: 33 1 44 38 91 03

28 Rue du Docteur Roux, 75015 Paris, France

Website

Dr. Anavaj Sakuntabhai is a researcher specializing in human genetics of infectious diseases. He received his MD from Chulalongkorn University in Bangkok, Thailand and completed post-doctoral training in Internal Medicine and Dermatology at the Ramathibodi Hospital, Mahidol University. He also has a MD from the University of Newcastle in Tyne, UK.  Finally, he earned his PhD in Human Molecular Genetics from the University of Oxford. He joined the Institut Pasteur in Paris in 2000 as a Senior Scientist and in 2007 became the leader of the Laboratory of Genetics of Human Response to Infections. In 2010 he created and became the head of the Functional Genetics of Infectious Diseases Unit.

The Functional Genetics of Infectious Diseases unit studies the basis of human genetic susceptibility to major human pathogens. They currently focus on mosquito-borne infections (malaria and dengue). They aim to identify genes governing infection outcome and transmissibility, within two important contexts: 1) That of the pathogen exploitation of the host and maximization of onward transmission; 2) The environmental context, placing emphasis upon the exogenous factors that impact upon the within-host dynamic of the pathogen and thus influence the outcome of infection.

Recent Publications

  • Levillayer, L, Brighelli, C, Demeret, C, Sakuntabhai, A, Bureau, JF. Role of two modules controlling the interaction between SKAP1 and SRC kinases comparison with SKAP2 architecture and consequences for evolution. PLoS One. 2024;19 (3):e0296230. doi: 10.1371/journal.pone.0296230. PubMed PMID:38483858 PubMed Central PMC10939263.
  • Teiti, I, Aubry, M, Fernandes-Pellerin, S, Patin, E, Madec, Y, Boucheron, P et al.. Unravelling the determinants of human health in French Polynesia: the MATAEA project. Front Epidemiol. 2023;3 :1201038. doi: 10.3389/fepid.2023.1201038. PubMed PMID:38455935 PubMed Central PMC10911015.
  • Tawfik, A, Kawaguchi, T, Takahashi, M, Setoh, K, Yamaguchi, I, Tabara, Y et al.. Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine. Vaccines (Basel). 2024;12 (2):. doi: 10.3390/vaccines12020136. PubMed PMID:38400120 PubMed Central PMC10892001.
  • Sene, O, Sagne, SN, Ngom, D, Diagne, MM, Badji, A, Khoulé, A et al.. Emergence of Crimean-Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022. Viruses. 2024;16 (2):. doi: 10.3390/v16020315. PubMed PMID:38400090 PubMed Central PMC10891565.
  • Saint-André, V, Charbit, B, Biton, A, Rouilly, V, Possémé, C, Bertrand, A et al.. Smoking changes adaptive immunity with persistent effects. Nature. 2024;626 (8000):827-835. doi: 10.1038/s41586-023-06968-8. PubMed PMID:38355791 PubMed Central PMC10881394.
  • Dott, T, Culina, S, Chemali, R, Mansour, CA, Dubois, F, Jagla, B et al.. Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies. Cytometry A. 2024;105 (2):124-138. doi: 10.1002/cyto.a.24801. PubMed PMID:37751141 .
  • Tawfik, A, Kawaguchi, T, Takahashi, M, Setoh, K, Yamaguchi, I, Tabara, Y et al.. Trivalent inactivated influenza vaccine response and immunogenicity assessment after one week and three months in repeatedly vaccinated adults. Expert Rev Vaccines. 2023;22 (1):826-838. doi: 10.1080/14760584.2023.2262563. PubMed PMID:37747798 .
  • COVID-19 Host Genetics Initiative. A second update on mapping the human genetic architecture of COVID-19. Nature. 2023;621 (7977):E7-E26. doi: 10.1038/s41586-023-06355-3. PubMed PMID:37674002 PubMed Central PMC10482689.
  • Villain, E, Chanson, A, Mainka, M, Kampschulte, N, Le Faouder, P, Bertrand-Michel, J et al.. Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks. iScience. 2023;26 (8):107422. doi: 10.1016/j.isci.2023.107422. PubMed PMID:37575177 PubMed Central PMC10415927.
  • Ceruti, A, Dia, N, Bakarey, AS, Ssekitoleko, J, Andriamandimby, SF, Malwengo-Kasongo, P et al.. A multi-country phase 2 study to evaluate the suitcase lab for rapid detection of SARS-CoV-2 in seven Sub-Saharan African countries: Lessons from the field. J Clin Virol. 2023;162 :105422. doi: 10.1016/j.jcv.2023.105422. PubMed PMID:36989731 PubMed Central PMC9981265.
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