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Anavaj Sakuntabhai

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Anavaj Sakuntabhai

Head, Functional Genetics of Infectious Diseases, Pasteur Institute

Email: anavaj@pasteur.fr
Phone: 33 1 44 38 91 03

28 Rue du Docteur Roux, 75015 Paris, France

Website

Dr. Anavaj Sakuntabhai is a researcher specializing in human genetics of infectious diseases. He received his MD from Chulalongkorn University in Bangkok, Thailand and completed post-doctoral training in Internal Medicine and Dermatology at the Ramathibodi Hospital, Mahidol University. He also has a MD from the University of Newcastle in Tyne, UK.  Finally, he earned his PhD in Human Molecular Genetics from the University of Oxford. He joined the Institut Pasteur in Paris in 2000 as a Senior Scientist and in 2007 became the leader of the Laboratory of Genetics of Human Response to Infections. In 2010 he created and became the head of the Functional Genetics of Infectious Diseases Unit.

The Functional Genetics of Infectious Diseases unit studies the basis of human genetic susceptibility to major human pathogens. They currently focus on mosquito-borne infections (malaria and dengue). They aim to identify genes governing infection outcome and transmissibility, within two important contexts: 1) That of the pathogen exploitation of the host and maximization of onward transmission; 2) The environmental context, placing emphasis upon the exogenous factors that impact upon the within-host dynamic of the pathogen and thus influence the outcome of infection.

Recent Publications

  • Bellone, R, Lequime, S, Jupille, H, Göertz, GP, Aubry, F, Mousson, L et al.. Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection. Sci Rep. 2020;10 (1):18404. doi: 10.1038/s41598-020-75042-4. PubMed PMID:33110109 PubMed Central PMC7591890.
  • Matangkasombut, P, Manopwisedjaroen, K, Pitabut, N, Thaloengsok, S, Suraamornkul, S, Yingtaweesak, T et al.. Dengue viremia kinetics in asymptomatic and symptomatic infection. Int J Infect Dis. 2020;101 :90-97. doi: 10.1016/j.ijid.2020.09.1446. PubMed PMID:32992011 .
  • Bastard, P, Rosen, LB, Zhang, Q, Michailidis, E, Hoffmann, HH, Zhang, Y et al.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370 (6515):. doi: 10.1126/science.abd4585. PubMed PMID:32972996 .
  • Dussart, P, Duong, V, Bleakley, K, Fortas, C, Lorn Try, P, Kim, KS et al.. Comparison of dengue case classification schemes and evaluation of biological changes in different dengue clinical patterns in a longitudinal follow-up of hospitalized children in Cambodia. PLoS Negl Trop Dis. 2020;14 (9):e0008603. doi: 10.1371/journal.pntd.0008603. PubMed PMID:32925941 PubMed Central PMC7515206.
  • Bonam, SR, Kaveri, SV, Sakuntabhai, A, Gilardin, L, Bayry, J. Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients. Cell Rep Med. 2020;1 (2):100016. doi: 10.1016/j.xcrm.2020.100016. PubMed PMID:32562483 PubMed Central PMC7190525.
  • Faye, O, de Lourdes Monteiro, M, Vrancken, B, Prot, M, Lequime, S, Diarra, M et al.. Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde. Emerg Infect Dis. 2020;26 (6):1084-1090. doi: 10.3201/eid2606.190928. PubMed PMID:32441631 PubMed Central PMC7258482.
  • Teissier, Y, Paul, R, Aubry, M, Rodo, X, Dommar, C, Salje, H et al.. Long-term persistence of monotypic dengue transmission in small size isolated populations, French Polynesia, 1978-2014. PLoS Negl Trop Dis. 2020;14 (3):e0008110. doi: 10.1371/journal.pntd.0008110. PubMed PMID:32142511 PubMed Central PMC7080275.
  • Manet, C, Simon-Lorière, E, Jouvion, G, Hardy, D, Prot, M, Conquet, L et al.. Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b. J Virol. 2020;94 (3):. doi: 10.1128/JVI.01034-19. PubMed PMID:31694939 PubMed Central PMC7000970.
  • Díez-Fuertes, F, De La Torre-Tarazona, HE, Calonge, E, Pernas, M, Alonso-Socas, MDM, Capa, L et al.. Transcriptome Sequencing of Peripheral Blood Mononuclear Cells from Elite Controller-Long Term Non Progressors. Sci Rep. 2019;9 (1):14265. doi: 10.1038/s41598-019-50642-x. PubMed PMID:31582776 PubMed Central PMC6776652.
  • Scepanovic, P, Hodel, F, Mondot, S, Partula, V, Byrd, A, Hammer, C et al.. A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals. Microbiome. 2019;7 (1):130. doi: 10.1186/s40168-019-0747-x. PubMed PMID:31519223 PubMed Central PMC6744716.
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