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Anavaj Sakuntabhai

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Anavaj Sakuntabhai

Head, Functional Genetics of Infectious Diseases, Pasteur Institute

Email: anavaj@pasteur.fr
Phone: 33 1 44 38 91 03

28 Rue du Docteur Roux, 75015 Paris, France

Website

Dr. Anavaj Sakuntabhai is a researcher specializing in human genetics of infectious diseases. He received his MD from Chulalongkorn University in Bangkok, Thailand and completed post-doctoral training in Internal Medicine and Dermatology at the Ramathibodi Hospital, Mahidol University. He also has a MD from the University of Newcastle in Tyne, UK.  Finally, he earned his PhD in Human Molecular Genetics from the University of Oxford. He joined the Institut Pasteur in Paris in 2000 as a Senior Scientist and in 2007 became the leader of the Laboratory of Genetics of Human Response to Infections. In 2010 he created and became the head of the Functional Genetics of Infectious Diseases Unit.

The Functional Genetics of Infectious Diseases unit studies the basis of human genetic susceptibility to major human pathogens. They currently focus on mosquito-borne infections (malaria and dengue). They aim to identify genes governing infection outcome and transmissibility, within two important contexts: 1) That of the pathogen exploitation of the host and maximization of onward transmission; 2) The environmental context, placing emphasis upon the exogenous factors that impact upon the within-host dynamic of the pathogen and thus influence the outcome of infection.

Recent Publications

  • Bastard, P, Gervais, A, Le Voyer, T, Rosain, J, Philippot, Q, Manry, J et al.. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Sci Immunol. 2021;6 (62):. doi: 10.1126/sciimmunol.abl4340. PubMed PMID:34413139 PubMed Central PMC8521484.
  • Bournazos, S, Vo, HTM, Duong, V, Auerswald, H, Ly, S, Sakuntabhai, A et al.. Antibody fucosylation predicts disease severity in secondary dengue infection. Science. 2021;372 (6546):1102-1105. doi: 10.1126/science.abc7303. PubMed PMID:34083490 PubMed Central PMC8262508.
  • Poonpanichakul, T, Chan-In, W, Opasawatchai, A, Loison, F, Matangkasombut, O, Charoensawan, V et al.. Innate Lymphoid Cells Activation and Transcriptomic Changes in Response to Human Dengue Infection. Front Immunol. 2021;12 :599805. doi: 10.3389/fimmu.2021.599805. PubMed PMID:34079535 PubMed Central PMC8165392.
  • Chansard, A, Dubrulle, N, Poujol de Molliens, M, Falanga, PB, Stephen, T, Hasan, M et al.. Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols. Front Immunol. 2021;12 :685768. doi: 10.3389/fimmu.2021.685768. PubMed PMID:33981321 PubMed Central PMC8109174.
  • Inizan, C, Minier, M, Prot, M, O'Connor, O, Forfait, C, Laumond, S et al.. Viral evolution sustains a dengue outbreak of enhanced severity. Emerg Microbes Infect. 2021;10 (1):536-544. doi: 10.1080/22221751.2021.1899057. PubMed PMID:33686914 PubMed Central PMC8011692.
  • Torres, MC, Lima de Mendonça, MC, Damasceno Dos Santos Rodrigues, C, Fonseca, V, Ribeiro, MS, Brandão, AP et al.. Dengue Virus Serotype 2 Intrahost Diversity in Patients with Different Clinical Outcomes. Viruses. 2021;13 (2):. doi: 10.3390/v13020349. PubMed PMID:33672226 PubMed Central PMC7926750.
  • Menegatti, S, Guillemot, V, Latis, E, Yahia-Cherbal, H, Mittermüller, D, Rouilly, V et al.. Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo. Ann Rheum Dis. 2020; :. doi: 10.1136/annrheumdis-2020-218304. PubMed PMID:33268443 PubMed Central PMC7958106.
  • Bellone, R, Lequime, S, Jupille, H, Göertz, GP, Aubry, F, Mousson, L et al.. Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection. Sci Rep. 2020;10 (1):18404. doi: 10.1038/s41598-020-75042-4. PubMed PMID:33110109 PubMed Central PMC7591890.
  • Matangkasombut, P, Manopwisedjaroen, K, Pitabut, N, Thaloengsok, S, Suraamornkul, S, Yingtaweesak, T et al.. Dengue viremia kinetics in asymptomatic and symptomatic infection. Int J Infect Dis. 2020;101 :90-97. doi: 10.1016/j.ijid.2020.09.1446. PubMed PMID:32992011 .
  • Bastard, P, Rosen, LB, Zhang, Q, Michailidis, E, Hoffmann, HH, Zhang, Y et al.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370 (6515):. doi: 10.1126/science.abd4585. PubMed PMID:32972996 PubMed Central PMC7857397.
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