Anavaj Sakuntabhai

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Anavaj Sakuntabhai

Head, Functional Genetics of Infectious Diseases, Pasteur Institute

Email: anavaj@pasteur.fr
Phone: 33 1 44 38 91 03

28 Rue du Docteur Roux, 75015 Paris, France


Dr. Anavaj Sakuntabhai is a researcher specializing in human genetics of infectious diseases. He received his MD from Chulalongkorn University in Bangkok, Thailand and completed post-doctoral training in Internal Medicine and Dermatology at the Ramathibodi Hospital, Mahidol University. He also has a MD from the University of Newcastle in Tyne, UK.  Finally, he earned his PhD in Human Molecular Genetics from the University of Oxford. He joined the Institut Pasteur in Paris in 2000 as a Senior Scientist and in 2007 became the leader of the Laboratory of Genetics of Human Response to Infections. In 2010 he created and became the head of the Functional Genetics of Infectious Diseases Unit.

The Functional Genetics of Infectious Diseases unit studies the basis of human genetic susceptibility to major human pathogens. They currently focus on mosquito-borne infections (malaria and dengue). They aim to identify genes governing infection outcome and transmissibility, within two important contexts: 1) That of the pathogen exploitation of the host and maximization of onward transmission; 2) The environmental context, placing emphasis upon the exogenous factors that impact upon the within-host dynamic of the pathogen and thus influence the outcome of infection.

Recent Publications

  • Inizan, C, Minier, M, Prot, M, O'Connor, O, Forfait, C, Laumond, S et al.. Viral evolution sustains a dengue outbreak of enhanced severity. Emerg Microbes Infect. 2021;10 (1):536-544. doi: 10.1080/22221751.2021.1899057. PubMed PMID:33686914 PubMed Central PMC8011692.
  • Torres, MC, Lima de Mendonça, MC, Damasceno Dos Santos Rodrigues, C, Fonseca, V, Ribeiro, MS, Brandão, AP et al.. Dengue Virus Serotype 2 Intrahost Diversity in Patients with Different Clinical Outcomes. Viruses. 2021;13 (2):. doi: 10.3390/v13020349. PubMed PMID:33672226 PubMed Central PMC7926750.
  • Menegatti, S, Guillemot, V, Latis, E, Yahia-Cherbal, H, Mittermüller, D, Rouilly, V et al.. Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo. Ann Rheum Dis. 2020; :. doi: 10.1136/annrheumdis-2020-218304. PubMed PMID:33268443 PubMed Central PMC7958106.
  • Bellone, R, Lequime, S, Jupille, H, Göertz, GP, Aubry, F, Mousson, L et al.. Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection. Sci Rep. 2020;10 (1):18404. doi: 10.1038/s41598-020-75042-4. PubMed PMID:33110109 PubMed Central PMC7591890.
  • Matangkasombut, P, Manopwisedjaroen, K, Pitabut, N, Thaloengsok, S, Suraamornkul, S, Yingtaweesak, T et al.. Dengue viremia kinetics in asymptomatic and symptomatic infection. Int J Infect Dis. 2020;101 :90-97. doi: 10.1016/j.ijid.2020.09.1446. PubMed PMID:32992011 .
  • Bastard, P, Rosen, LB, Zhang, Q, Michailidis, E, Hoffmann, HH, Zhang, Y et al.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020;370 (6515):. doi: 10.1126/science.abd4585. PubMed PMID:32972996 PubMed Central PMC7857397.
  • Dussart, P, Duong, V, Bleakley, K, Fortas, C, Lorn Try, P, Kim, KS et al.. Comparison of dengue case classification schemes and evaluation of biological changes in different dengue clinical patterns in a longitudinal follow-up of hospitalized children in Cambodia. PLoS Negl Trop Dis. 2020;14 (9):e0008603. doi: 10.1371/journal.pntd.0008603. PubMed PMID:32925941 PubMed Central PMC7515206.
  • Bonam, SR, Kaveri, SV, Sakuntabhai, A, Gilardin, L, Bayry, J. Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients. Cell Rep Med. 2020;1 (2):100016. doi: 10.1016/j.xcrm.2020.100016. PubMed PMID:32562483 PubMed Central PMC7190525.
  • Faye, O, de Lourdes Monteiro, M, Vrancken, B, Prot, M, Lequime, S, Diarra, M et al.. Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde. Emerg Infect Dis. 2020;26 (6):1084-1090. doi: 10.3201/eid2606.190928. PubMed PMID:32441631 PubMed Central PMC7258482.
  • Teissier, Y, Paul, R, Aubry, M, Rodo, X, Dommar, C, Salje, H et al.. Long-term persistence of monotypic dengue transmission in small size isolated populations, French Polynesia, 1978-2014. PLoS Negl Trop Dis. 2020;14 (3):e0008110. doi: 10.1371/journal.pntd.0008110. PubMed PMID:32142511 PubMed Central PMC7080275.
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