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Robert Sladek

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Robert Sladek

Assistant Professor, Department of Human Genetics

Email: robert.sladek@mcgill.ca
Phone: (514) 398-5458

740 Dr Penfield Ave, Room 6214
Montréal, Québec, Canada, H3A 0G1

Rob Sladek is an Assistant Professor at the McGill University and Genome Quebec Innovation Centre. He completed undergraduate studies in Engineering Science and Medicine as well as a clinical fellowship in Endocrinology and Metabolism, all at the University of Toronto. His postdoctoral training explored the role of the Estrogen-related receptors in the regulation of fat metabolism and reproduction (with Dr Vincent Giguère) and the application of high-throughput genomics technologies to study complex traits (with Dr Tom Hudson). His current research centers on the development of new technologies for studying the dynamics of gene transcription networks in living cells (the Living Microarray Project) and risk factors for type 2 diabetes (the Diabetes Gene Discovery Group).

Research Interests

Dr Sladek’s scientific contributions centre on establishing the role of gene transcription networks in complex traits. He identified key physiological roles for the orphan nuclear receptor ERRalpha in regulating the balance between lipolysis and lipogenesis and ERRbeta in regulating development of the chorion and trophoblast. He has developed methods to identify transcriptional networks de novo in panels of recombinant congenic mouse strains and to characterize transcriptional effects of cis-regulatory genetic variants that underlie complex genetic traits. His ongoing research projects include collaboration with Dr. Walter Reisner (McGill Physics) to develop nanodevices to characterize single DNA molecules.

Recent Publications

  • Zhang, W, Lu, T, Sladek, R, Li, Y, Najafabadi, H, Dupuis, J et al.. SharePro: an accurate and efficient genetic colocalization method accounting for multiple causal signals. Bioinformatics. 2024;40 (5):. doi: 10.1093/bioinformatics/btae295. PubMed PMID:38688586 PubMed Central PMC11105950.
  • Kwak, SH, Hernandez-Cancela, RB, DiCorpo, DA, Condon, DE, Merino, J, Wu, P et al.. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. Diabetes Care. 2024;47 (6):1042-1047. doi: 10.2337/dc23-2274. PubMed PMID:38652672 .
  • Yu, V, Yong, F, Marta, A, Khadayate, S, Osakwe, A, Bhattacharya, S et al.. Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity. Diabetologia. 2024;67 (6):1079-1094. doi: 10.1007/s00125-024-06123-6. PubMed PMID:38512414 PubMed Central PMC11058053.
  • Ghosh, A, Leung, YH, Yu, J, Sladek, R, Chénier, I, Oppong, AK et al.. Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling. Biochim Biophys Acta Mol Cell Biol Lipids. 2024;1869 (3):159461. doi: 10.1016/j.bbalip.2024.159461. PubMed PMID:38272177 .
  • Yu, V, Yong, F, Marta, A, Khadayate, S, Osakwe, A, Bhattacharya, S et al.. Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity. bioRxiv. 2023; :. doi: 10.1101/2023.02.04.527050. PubMed PMID:38076935 PubMed Central PMC10705251.
  • Kiss, RS, Chicoine, J, Khalil, Y, Sladek, R, Chen, H, Pisaturo, A et al.. Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis. J Biol Chem. 2023;299 (11):105295. doi: 10.1016/j.jbc.2023.105295. PubMed PMID:37774976 PubMed Central PMC10641524.
  • Kwak, SH, Hernandez-Cancela, RB, DiCorpo, DA, Condon, DE, Merino, J, Wu, P et al.. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus. medRxiv. 2023; :. doi: 10.1101/2023.07.25.23293180. PubMed PMID:37546893 PubMed Central PMC10402212.
  • Costanzo, MC, von Grotthuss, M, Massung, J, Jang, D, Caulkins, L, Koesterer, R et al.. The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits. Cell Metab. 2023;35 (4):695-710.e6. doi: 10.1016/j.cmet.2023.03.001. PubMed PMID:36963395 PubMed Central PMC10231654.
  • Chabosseau, P, Yong, F, Delgadillo-Silva, LF, Lee, EY, Melhem, R, Li, S et al.. Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq". Life Sci. 2023;316 :121436. doi: 10.1016/j.lfs.2023.121436. PubMed PMID:36706832 .
  • Sladek, R. Predicting the response to GLP-1 receptor agonists: an unexpected role for β-arrestin-1. Lancet Diabetes Endocrinol. 2023;11 (1):3-4. doi: 10.1016/S2213-8587(22)00357-6. PubMed PMID:36528348 .
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