Robert Sladek

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Robert Sladek

Assistant Professor, Department of Human Genetics

Email: robert.sladek@mcgill.ca
Phone: (514) 398-5458

740 Dr Penfield Ave, Room 6214
Montréal, Québec, Canada, H3A 0G1

Rob Sladek is an Assistant Professor at the McGill University and Genome Quebec Innovation Centre. He completed undergraduate studies in Engineering Science and Medicine as well as a clinical fellowship in Endocrinology and Metabolism, all at the University of Toronto. His postdoctoral training explored the role of the Estrogen-related receptors in the regulation of fat metabolism and reproduction (with Dr Vincent Giguère) and the application of high-throughput genomics technologies to study complex traits (with Dr Tom Hudson). His current research centers on the development of new technologies for studying the dynamics of gene transcription networks in living cells (the Living Microarray Project) and risk factors for type 2 diabetes (the Diabetes Gene Discovery Group).

Research Interests

Dr Sladek’s scientific contributions centre on establishing the role of gene transcription networks in complex traits. He identified key physiological roles for the orphan nuclear receptor ERRalpha in regulating the balance between lipolysis and lipogenesis and ERRbeta in regulating development of the chorion and trophoblast. He has developed methods to identify transcriptional networks de novo in panels of recombinant congenic mouse strains and to characterize transcriptional effects of cis-regulatory genetic variants that underlie complex genetic traits. Most recently, he collaborated with Drs Froguel, Polychronakos, Posner and Prentki to complete the first genome-wide association study (GWAS) to identify risk loci for type 2 diabetes.

Recent Publications

  • Kessler, MD, Loesch, DP, Perry, JA, Heard-Costa, NL, Taliun, D, Cade, BE et al.. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc. Natl. Acad. Sci. U.S.A. 2020;117 (5):2560-2569. doi: 10.1073/pnas.1902766117. PubMed PMID:31964835 PubMed Central PMC7007577.
  • Yao, S, Kuja-Halkola, R, Martin, J, Lu, Y, Lichtenstein, P, Norring, C et al.. Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biol. Psychiatry. 2019;86 (8):577-586. doi: 10.1016/j.biopsych.2019.04.036. PubMed PMID:31301758 PubMed Central PMC6776821.
  • Dias, C, Elzein, S, Sladek, R, Goodyer, CG. Sex-specific effects of a microsatellite polymorphism on human growth hormone receptor gene expression. Mol. Cell. Endocrinol. 2019;492 :110442. doi: 10.1016/j.mce.2019.05.001. PubMed PMID:31063794 .
  • Mancini, M, Caignard, G, Charbonneau, B, Dumaine, A, Wu, N, Leiva-Torres, GA et al.. Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis. J. Immunol. 2019;202 (5):1479-1493. doi: 10.4049/jimmunol.1800063. PubMed PMID:30683700 .
  • Coyne, ES, Bedard, N, Wykes, L, Stretch, C, Jammoul, S, Li, S et al.. Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling. Endocrinology. 2018;159 (8):2966-2977. doi: 10.1210/en.2018-00290. PubMed PMID:29901692 .
  • Mahshid, S, Lu, J, Abidi, AA, Sladek, R, Reisner, WW, Ahamed, MJ et al.. Transverse dielectrophoretic-based DNA nanoscale confinement. Sci Rep. 2018;8 (1):5981. doi: 10.1038/s41598-018-24132-5. PubMed PMID:29654238 PubMed Central PMC5899125.
  • Dali, R, Verginelli, F, Pramatarova, A, Sladek, R, Stifani, S. Characterization of a FOXG1:TLE1 transcriptional network in glioblastoma-initiating cells. Mol Oncol. 2018;12 (6):775-787. doi: 10.1002/1878-0261.12168. PubMed PMID:29316219 PubMed Central PMC5983107.
  • Jun, G, Manning, A, Almeida, M, Zawistowski, M, Wood, AR, Teslovich, TM et al.. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (2):379-384. doi: 10.1073/pnas.1705859115. PubMed PMID:29279374 PubMed Central PMC5777025.
  • Wheeler, E, Leong, A, Liu, CT, Hivert, MF, Strawbridge, RJ, Podmore, C et al.. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Med. 2017;14 (9):e1002383. doi: 10.1371/journal.pmed.1002383. PubMed PMID:28898252 PubMed Central PMC5595282.
  • Kanagaratham, C, Camateros, P, Ren, J, Sladek, R, Vidal, SM, Radzioch, D et al.. Mouse Chromosome 4 Is Associated with the Baseline and Allergic IgE Phenotypes. G3 (Bethesda). 2017;7 (8):2559-2564. doi: 10.1534/g3.117.042739. PubMed PMID:28696925 PubMed Central PMC5555462.
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