Robert Sladek

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Robert Sladek

Assistant Professor, Department of Human Genetics

Email: robert.sladek@mcgill.ca
Phone: (514) 398-5458

740 Dr Penfield Ave, Room 6214
Montréal, Québec, Canada, H3A 0G1

Rob Sladek is an Assistant Professor at the McGill University and Genome Quebec Innovation Centre. He completed undergraduate studies in Engineering Science and Medicine as well as a clinical fellowship in Endocrinology and Metabolism, all at the University of Toronto. His postdoctoral training explored the role of the Estrogen-related receptors in the regulation of fat metabolism and reproduction (with Dr Vincent Giguère) and the application of high-throughput genomics technologies to study complex traits (with Dr Tom Hudson). His current research centers on the development of new technologies for studying the dynamics of gene transcription networks in living cells (the Living Microarray Project) and risk factors for type 2 diabetes (the Diabetes Gene Discovery Group).

Research Interests

Dr Sladek’s scientific contributions centre on establishing the role of gene transcription networks in complex traits. He identified key physiological roles for the orphan nuclear receptor ERRalpha in regulating the balance between lipolysis and lipogenesis and ERRbeta in regulating development of the chorion and trophoblast. He has developed methods to identify transcriptional networks de novo in panels of recombinant congenic mouse strains and to characterize transcriptional effects of cis-regulatory genetic variants that underlie complex genetic traits. His ongoing research projects include collaboration with Dr. Walter Reisner (McGill Physics) to develop nanodevices to characterize single DNA molecules.

Recent Publications

  • Kiss, RS, Chicoine, J, Khalil, Y, Sladek, R, Chen, H, Pisaturo, A et al.. Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis. J Biol Chem. 2023;299 (11):105295. doi: 10.1016/j.jbc.2023.105295. PubMed PMID:37774976 PubMed Central PMC10641524.
  • Kwak, SH, Hernandez-Cancela, RB, DiCorpo, DA, Condon, DE, Merino, J, Wu, P et al.. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus. medRxiv. 2023; :. doi: 10.1101/2023.07.25.23293180. PubMed PMID:37546893 PubMed Central PMC10402212.
  • Costanzo, MC, von Grotthuss, M, Massung, J, Jang, D, Caulkins, L, Koesterer, R et al.. The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits. Cell Metab. 2023;35 (4):695-710.e6. doi: 10.1016/j.cmet.2023.03.001. PubMed PMID:36963395 PubMed Central PMC10231654.
  • Chabosseau, P, Yong, F, Delgadillo-Silva, LF, Lee, EY, Melhem, R, Li, S et al.. Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq". Life Sci. 2023;316 :121436. doi: 10.1016/j.lfs.2023.121436. PubMed PMID:36706832 .
  • Sladek, R. Predicting the response to GLP-1 receptor agonists: an unexpected role for β-arrestin-1. Lancet Diabetes Endocrinol. 2023;11 (1):3-4. doi: 10.1016/S2213-8587(22)00357-6. PubMed PMID:36528348 .
  • Al-Mass, A, Poursharifi, P, Peyot, ML, Lussier, R, Chenier, I, Leung, YH et al.. Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia. Mol Metab. 2022;66 :101609. doi: 10.1016/j.molmet.2022.101609. PubMed PMID:36198384 PubMed Central PMC9579801.
  • Vivoli, A, Ghislain, J, Filali-Mouhim, A, Angeles, ZE, Castell, AL, Sladek, R et al.. Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid-Induced Rat β-Cell Proliferation. Diabetes. 2023;72 (1):45-58. doi: 10.2337/db22-0121. PubMed PMID:36191509 PubMed Central PMC9797324.
  • DiCorpo, D, Gaynor, SM, Russell, EM, Westerman, KE, Raffield, LM, Majarian, TD et al.. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program. Commun Biol. 2022;5 (1):756. doi: 10.1038/s42003-022-03702-4. PubMed PMID:35902682 PubMed Central PMC9334637.
  • Seth, S, Rand, A, Reisner, W, Dunbar, WB, Sladek, R, Bhattacharya, A et al.. Discriminating protein tags on a dsDNA construct using a Dual Nanopore Device. Sci Rep. 2022;12 (1):11305. doi: 10.1038/s41598-022-14609-9. PubMed PMID:35787637 PubMed Central PMC9253098.
  • Al-Mass, A, Poursharifi, P, Peyot, ML, Lussier, R, Levens, EJ, Guida, J et al.. Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress. Mol Metab. 2022;60 :101471. doi: 10.1016/j.molmet.2022.101471. PubMed PMID:35272070 PubMed Central PMC8972011.
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