Mark Lathrop

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Mark Lathrop

Professor, Department of Human Genetics

Email: directoradmin.genome@mcgill.ca
Phone: (514) 398-6583

740 Dr Penfield Ave, Room 6105
Montréal, Québec, Canada, H3A 0G1

Professor Lathrop’s areas of research interest lie in the application of genomics and statistical methods to understand the molecular basis of human disease. He joined the McGill University in 2011 where he is Professor in the Department of Human Genetics and Scientific Director of the McGill Genome Centre. Dr. Lathrop was trained in theoretical statistics and genetics at the University of Washington. After obtaining his PhD, he moved to France where he was one of the founding members of the CEPH, which pioneered the international collaboration on the human genome in the 1980s and 1990s. In 1993, he moved to the University of Oxford, where he was a Wellcome Trust Principal Fellow and Professor of Human Genetics. At the University of Oxford he was the co-founder and first scientific director of the Wellcome Trust Centre for Human Genetics, an institute created to apply genomic approaches to understanding the molecular basis of human disease. At the request of the French government he returned to France in 1998 to found the centre National de Génotypage which developed into the principal national infrastructure for human genetic studies in France.. In 2005, the French government asked Pr. Lathrop to serve also as the scientific director of the Fondation Jean Dausset – Centre d’Etude du Polymorphism. He held these responsibilities until taking up his position at McGill.

Recent Publications

  • Mehvari, S, Karimian Fathi, N, Saki, S, Asadnezhad, M, Arzhangi, S, Ghodratpour, F et al.. Contribution of genetic variants in the development of familial premature coronary artery disease in a cohort of cardiac patients. Clin Genet. 2024;105 (6):611-619. doi: 10.1111/cge.14491. PubMed PMID:38308583 .
  • Tin, A, Fohner, AE, Yang, Q, Brody, JA, Davies, G, Yao, J et al.. Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Commun Biol. 2023;6 (1):1117. doi: 10.1038/s42003-023-05454-1. PubMed PMID:37923804 PubMed Central PMC10624811.
  • Le Grand, Q, Ecker Ferreira, L, Metso, TM, Schilling, S, Tatlisumak, T, Grond-Ginsbach, C et al.. Genetic Insights on the Relation of Vascular Risk Factors and Cervical Artery Dissection. J Am Coll Cardiol. 2023;82 (14):1411-1423. doi: 10.1016/j.jacc.2023.07.021. PubMed PMID:37758436 .
  • COVID-19 Host Genetics Initiative. A second update on mapping the human genetic architecture of COVID-19. Nature. 2023;621 (7977):E7-E26. doi: 10.1038/s41586-023-06355-3. PubMed PMID:37674002 PubMed Central PMC10482689.
  • Duperron, MG, Knol, MJ, Le Grand, Q, Evans, TE, Mishra, A, Tsuchida, A et al.. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. Nat Med. 2023;29 (4):950-962. doi: 10.1038/s41591-023-02268-w. PubMed PMID:37069360 PubMed Central PMC10115645.
  • Yu Chen, H, Dina, C, Small, AM, Shaffer, CM, Levinson, RT, Helgadóttir, A et al.. Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. Eur Heart J. 2023;44 (21):1927-1939. doi: 10.1093/eurheartj/ehad142. PubMed PMID:37038246 PubMed Central PMC10232274.
  • Yakneen, S, Waszak, SM, PCAWG Technical Working Group, Gertz, M, Korbel, JO, PCAWG Consortium et al.. Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes. Nat Biotechnol. 2023;41 (4):577. doi: 10.1038/s41587-022-01554-1. PubMed PMID:36944844 PubMed Central PMC10110458.
  • Rodriguez-Martin, B, Alvarez, EG, Baez-Ortega, A, Zamora, J, Supek, F, Demeulemeester, J et al.. Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat Genet. 2023;55 (6):1080. doi: 10.1038/s41588-023-01319-9. PubMed PMID:36944736 PubMed Central PMC10260396.
  • Akdemir, KC, Le, VT, Chandran, S, Li, Y, Verhaak, RG, Beroukhim, R et al.. Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat Genet. 2023;55 (6):1079. doi: 10.1038/s41588-023-01318-w. PubMed PMID:36944735 PubMed Central PMC10260394.
  • Zapatka, M, Borozan, I, Brewer, DS, Iskar, M, Grundhoff, A, Alawi, M et al.. Author Correction: The landscape of viral associations in human cancers. Nat Genet. 2023;55 (6):1077. doi: 10.1038/s41588-023-01316-y. PubMed PMID:36944734 PubMed Central PMC10260395.
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