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Mark Lathrop

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Mark Lathrop

Professor, Department of Human Genetics

Email: directoradmin.genome@mcgill.ca
Phone: (514) 398-6583

740 Dr Penfield Ave, Room 6105
Montréal, Québec, Canada, H3A 0G1

Professor Lathrop’s areas of research interest lie in the application of genomics and statistical methods to understand the molecular basis of human disease. He joined the McGill University in 2011 where he is Professor in the Department of Human Genetics and Scientific Director of the McGill University and Genome Quebec Innovation Centre. Dr. Lathrop was trained in theoretical statistics and genetics at the University of Washington. After obtaining his PhD, he moved to France where he was one of the founding members of the CEPH, which pioneered the international collaboration on the human genome in the 1980s and 1990s. In 1993, he moved to the University of Oxford, where he was a Wellcome Trust Principal Fellow and Professor of Human Genetics. At the University of Oxford he was the co-founder and first scientific director of the Wellcome Trust Centre for Human Genetics, an institute created to apply genomic approaches to understanding the molecular basis of human disease. At the request of the French government he returned to France in 1998 to found the centre National de Génotypage which developed into the principal national infrastructure for human genetic studies in France.. In 2005, the French government asked Pr. Lathrop to serve also as the scientific director of the Fondation Jean Dausset – Centre d’Etude du Polymorphism. He held these responsibilities until taking up his position at McGill.

Recent Publications

  • Mascarell Maričić, L, Walter, H, Rosenthal, A, Ripke, S, Quinlan, EB, Banaschewski, T et al.. The IMAGEN study: a decade of imaging genetics in adolescents. Mol. Psychiatry. 2020; :. doi: 10.1038/s41380-020-0822-5. PubMed PMID:32601453 .
  • Lahrouchi, N, Tadros, R, Crotti, L, Mizusawa, Y, Postema, PG, Beekman, L et al.. Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome. Circulation. 2020; :. doi: 10.1161/CIRCULATIONAHA.120.045956. PubMed PMID:32429735 .
  • Hornigold, N, Dunn, KR, Craven, RA, Zougman, A, Trainor, S, Shreeve, R et al.. Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion. Br. J. Cancer. 2020;123 (1):137-147. doi: 10.1038/s41416-020-0874-y. PubMed PMID:32390008 PubMed Central PMC7341846.
  • Landi, MT, Bishop, DT, MacGregor, S, Machiela, MJ, Stratigos, AJ, Ghiorzo, P et al.. Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nat. Genet. 2020;52 (5):494-504. doi: 10.1038/s41588-020-0611-8. PubMed PMID:32341527 PubMed Central PMC7255059.
  • Chen, HY, Cairns, BJ, Small, AM, Burr, HA, Ambikkumar, A, Martinsson, A et al.. Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis. JAMA Cardiol. 2020; :. doi: 10.1001/jamacardio.2020.0246. PubMed PMID:32186652 PubMed Central PMC7081150.
  • Péan, N, Le Lay, A, Brial, F, Wasserscheid, J, Rouch, C, Vincent, M et al.. Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. Diabetologia. 2020;63 (6):1223-1235. doi: 10.1007/s00125-020-05122-7. PubMed PMID:32173762 PubMed Central PMC7228998.
  • Brial, F, Alzaid, F, Sonomura, K, Kamatani, Y, Meneyrol, K, Le Lay, A et al.. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Rep. 2020;30 (7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066. PubMed PMID:32075738 .
  • ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature. 2020;578 (7793):82-93. doi: 10.1038/s41586-020-1969-6. PubMed PMID:32025007 PubMed Central PMC7025898.
  • International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu, International Multiple Sclerosis Genetics Consortium. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell. 2020;180 (2):403. doi: 10.1016/j.cell.2020.01.002. PubMed PMID:31978348 PubMed Central PMC6978797.
  • Kennedy, JM, Georges, A, Bassenden, AV, Vidal, SM, Berghuis, AM, Taniuchi, I et al.. ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis. Infect. Immun. 2020;88 (2):. doi: 10.1128/IAI.00845-19. PubMed PMID:31792077 PubMed Central PMC6977123.
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