Mark Lathrop

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Mark Lathrop

Professor, Department of Human Genetics

Email: directoradmin.genome@mcgill.ca
Phone: (514) 398-6583

740 Dr Penfield Ave, Room 6105
Montréal, Québec, Canada, H3A 0G1

Professor Lathrop’s areas of research interest lie in the application of genomics and statistical methods to understand the molecular basis of human disease. He joined the McGill University in 2011 where he is Professor in the Department of Human Genetics and Scientific Director of the McGill Genome Centre. Dr. Lathrop was trained in theoretical statistics and genetics at the University of Washington. After obtaining his PhD, he moved to France where he was one of the founding members of the CEPH, which pioneered the international collaboration on the human genome in the 1980s and 1990s. In 1993, he moved to the University of Oxford, where he was a Wellcome Trust Principal Fellow and Professor of Human Genetics. At the University of Oxford he was the co-founder and first scientific director of the Wellcome Trust Centre for Human Genetics, an institute created to apply genomic approaches to understanding the molecular basis of human disease. At the request of the French government he returned to France in 1998 to found the centre National de Génotypage which developed into the principal national infrastructure for human genetic studies in France.. In 2005, the French government asked Pr. Lathrop to serve also as the scientific director of the Fondation Jean Dausset – Centre d’Etude du Polymorphism. He held these responsibilities until taking up his position at McGill.

Recent Publications

  • COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19. Nature. 2022;608 (7921):E1-E10. doi: 10.1038/s41586-022-04826-7. PubMed PMID:35922517 PubMed Central PMC9352569.
  • Shao, X, Le Stunff, C, Cheung, W, Kwan, T, Lathrop, M, Pastinen, T et al.. Differentially methylated CpGs in response to growth hormone administration in children with idiopathic short stature. Clin Epigenetics. 2022;14 (1):65. doi: 10.1186/s13148-022-01281-z. PubMed PMID:35585611 PubMed Central PMC9118695.
  • Mishra, A, Duplaà, C, Vojinovic, D, Suzuki, H, Sargurupremraj, M, Zilhão, NR et al.. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain. 2022;145 (6):1992-2007. doi: 10.1093/brain/awab432. PubMed PMID:35511193 PubMed Central PMC9255380.
  • Nastase, A, Mandal, A, Lu, SK, Anbunathan, H, Morris-Rosendahl, D, Zhang, YZ et al.. Author Correction: Integrated genomics point to immune vulnerabilities in pleural mesothelioma. Sci Rep. 2022;12 (1):4779. doi: 10.1038/s41598-022-08800-1. PubMed PMID:35314756 PubMed Central PMC8938505.
  • Forgetta, V, Li, R, Darmond-Zwaig, C, Belisle, A, Balion, C, Roshandel, D et al.. Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA). BMJ Open. 2022;12 (3):e059021. doi: 10.1136/bmjopen-2021-059021. PubMed PMID:35273064 PubMed Central PMC8915305.
  • Kousathanas, A, Pairo-Castineira, E, Rawlik, K, Stuckey, A, Odhams, CA, Walker, S et al.. Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature. 2022;607 (7917):97-103. doi: 10.1038/s41586-022-04576-6. PubMed PMID:35255492 PubMed Central PMC9259496.
  • Eumorphia Consortium. Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome. Nat Genet. 2022;54 (3):358-360. doi: 10.1038/s41588-022-01019-w. PubMed PMID:35169327 .
  • Škorić-Milosavljević, D, Tadros, R, Bosada, FM, Tessadori, F, van Weerd, JH, Woudstra, OI et al.. Common Genetic Variants Contribute to Risk of Transposition of the Great Arteries. Circ Res. 2022;130 (2):166-180. doi: 10.1161/CIRCRESAHA.120.317107. PubMed PMID:34886679 PubMed Central PMC8768504.
  • Routhier, J, Pons, S, Freidja, ML, Dalstein, V, Cutrona, J, Jonquet, A et al.. An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions. Nat Commun. 2021;12 (1):6384. doi: 10.1038/s41467-021-26637-6. PubMed PMID:34737286 PubMed Central PMC8568944.
  • Murall, CL, Fournier, E, Galvez, JH, N'Guessan, A, Reiling, SJ, Quirion, PO et al.. A small number of early introductions seeded widespread transmission of SARS-CoV-2 in Québec, Canada. Genome Med. 2021;13 (1):169. doi: 10.1186/s13073-021-00986-9. PubMed PMID:34706766 PubMed Central PMC8550813.
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