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Mark Lathrop

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Mark Lathrop

Professor, Department of Human Genetics

Email: directoradmin.genome@mcgill.ca
Phone: (514) 398-6583

740 Dr Penfield Ave, Room 6105
Montréal, Québec, Canada, H3A 0G1

Professor Lathrop’s areas of research interest lie in the application of genomics and statistical methods to understand the molecular basis of human disease. He joined the McGill University in 2011 where he is Professor in the Department of Human Genetics and Scientific Director of the McGill Genome Centre. Dr. Lathrop was trained in theoretical statistics and genetics at the University of Washington. After obtaining his PhD, he moved to France where he was one of the founding members of the CEPH, which pioneered the international collaboration on the human genome in the 1980s and 1990s. In 1993, he moved to the University of Oxford, where he was a Wellcome Trust Principal Fellow and Professor of Human Genetics. At the University of Oxford he was the co-founder and first scientific director of the Wellcome Trust Centre for Human Genetics, an institute created to apply genomic approaches to understanding the molecular basis of human disease. At the request of the French government he returned to France in 1998 to found the centre National de Génotypage which developed into the principal national infrastructure for human genetic studies in France.. In 2005, the French government asked Pr. Lathrop to serve also as the scientific director of the Fondation Jean Dausset – Centre d’Etude du Polymorphism. He held these responsibilities until taking up his position at McGill.

Recent Publications

  • Brial, F, Puel, G, Gonzalez, L, Russick, J, Auld, D, Lathrop, M et al.. Stimulation of insulin secretion induced by low 4-cresol dose involves the RPS6KA3 signalling pathway. PLoS One. 2024;19 (10):e0310370. doi: 10.1371/journal.pone.0310370. PubMed PMID:39446839 PubMed Central PMC11500888.
  • Domingo-Sabugo, C, Willis-Owen, SA, Mandal, A, Nastase, A, Dwyer, S, Brambilla, C et al.. Genomic analysis defines distinct pancreatic and neuronal subtypes of lung carcinoid. J Pathol. 2024;264 (3):332-343. doi: 10.1002/path.6352. PubMed PMID:39329437 .
  • Tschorn, M, Daedelow, L, Szalek, L, Banaschewski, T, Bokde, ALW, Desrivières, S et al.. Personality, Social Factors, Brain Functioning, Familial Risk, and Trajectories of Alcohol Misuse in Adolescence. JAMA Netw Open. 2024;7 (8):e2425114. doi: 10.1001/jamanetworkopen.2024.25114. PubMed PMID:39150713 PubMed Central PMC11329879.
  • Glennon, KI, Endo, M, Usui, Y, Iwasaki, Y, Breau, RH, Kapoor, A et al.. Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening. JCO Precis Oncol. 2024;8 :e2400094. doi: 10.1200/PO.24.00094. PubMed PMID:39088769 .
  • Debette, S, Caro, I, Western, D, Namba, S, Sun, N, Kawaguchi, S et al.. Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4535534/v1. PubMed PMID:39011113 PubMed Central PMC11247936.
  • Bougnères, P, Le Fur, S, Kamatani, Y, Mai, TN, Belot, MP, Perge, K et al.. Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes. J Hum Genet. 2024;69 (11):585-590. doi: 10.1038/s10038-024-01272-3. PubMed PMID:38982180 .
  • Le Grand, Q, Tsuchida, A, Koch, A, Imtiaz, MA, Aziz, NA, Vigneron, C et al.. Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease. Mol Psychiatry. 2024;29 (11):3567-3579. doi: 10.1038/s41380-024-02604-7. PubMed PMID:38811690 PubMed Central PMC11541005.
  • Mehvari, S, Karimian Fathi, N, Saki, S, Asadnezhad, M, Arzhangi, S, Ghodratpour, F et al.. Contribution of genetic variants in the development of familial premature coronary artery disease in a cohort of cardiac patients. Clin Genet. 2024;105 (6):611-619. doi: 10.1111/cge.14491. PubMed PMID:38308583 .
  • Tin, A, Fohner, AE, Yang, Q, Brody, JA, Davies, G, Yao, J et al.. Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Commun Biol. 2023;6 (1):1117. doi: 10.1038/s42003-023-05454-1. PubMed PMID:37923804 PubMed Central PMC10624811.
  • Le Grand, Q, Ecker Ferreira, L, Metso, TM, Schilling, S, Tatlisumak, T, Grond-Ginsbach, C et al.. Genetic Insights on the Relation of Vascular Risk Factors and Cervical Artery Dissection. J Am Coll Cardiol. 2023;82 (14):1411-1423. doi: 10.1016/j.jacc.2023.07.021. PubMed PMID:37758436 .
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