Head, Inflammation Genomics Lab
Departments of Human Genetics and Microbiology & Immunology
Phone: (514) 398-5844
Lab: (514) 398-5670
740 Dr Penfield Ave, Room 4203
Montréal, Québec, Canada, H3A 0G1
David Langlais is an Assistant Professor in the Departments of Human Genetics and Microbiology & Immunology at McGill University, and Principal Investigator at the McGill Genome Centre. Dr Langlais completed his Ph.D. with honors in Molecular Biology in 2011 under the supervision of Dr. Jacques Drouin at the IRCM. His work revealed the complex transcriptional regulation at play in the immuno-neuroendocrine interface and in the maintenance of pituitary tissue. Dr Langlais then pursued postdoctoral research in Dr Philippe Gros’ laboratory at McGill University where he studied the role of critical innate immunity transcription factors and participated in the characterization of new proteins involved in immune function and neuroinflammatory conditions, including cerebral malaria. Dr Langlais has received multiple awards and fellowships, including the Milstein Young Investigator Award from the International Cytokine and Interferon Society and the 2018 Top 10 Discovery by Quebec Science. His current research is founded on functional genomics, bioinformatics, genome editing and molecular biology methods to explain the transcriptional mechanisms involved in normal and pathological inflammation, aiming to identify and validate novel therapeutic targets for inflammatory diseases.
Acute and chronic diseases of inflammation are caused by uncontrolled activation of the immune system and by ineffective return to homeostasis following insult resolution. Environmental and genetic factors are contributing to immune dysregulation. On the genetic side, not only inter-individual variations are influencing the inflammatory responses, but also the epigenetic control of gene expression by transcription factors is important.
The aim of our lab is to understand the role of transcription factors in normal and pathological inflammatory responses. We use cutting-edge molecular biology and genomics methods to:
- Investigate the involvement of human genetic variations in chronic inflammatory diseases, such as Hashimoto thyroiditis.
- Identify and characterize the function of transcription factors in acute and chronic inflammation.
- Develop innovative anti-inflammatory treatments, especially to target cerebral malaria.
- Tung, LT, Wang, H, Belle, JI, Petrov, JC, Langlais, D, Nijnik, A et al.. p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress. Cell Death Dis. 2021;12 (10):923. doi: 10.1038/s41419-021-04202-9. PubMed PMID:34625535 PubMed Central PMC8501024.
- Lévy, R, Langlais, D, Béziat, V, Rapaport, F, Rao, G, Lazarov, T et al.. Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents. J Clin Invest. 2021;131 (17):. doi: 10.1172/JCI150143. PubMed PMID:34623332 PubMed Central PMC8409595.
- Shen, L, Pugsley, L, Cencic, R, Wang, H, Robert, F, Naineni, SK et al.. A forward genetic screen identifies modifiers of rocaglate responsiveness. Sci Rep. 2021;11 (1):18516. doi: 10.1038/s41598-021-97765-8. PubMed PMID:34531456 PubMed Central PMC8445955.
- Béziat, V, Rapaport, F, Hu, J, Titeux, M, Bonnet des Claustres, M, Bourgey, M et al.. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell. 2021;184 (14):3812-3828.e30. doi: 10.1016/j.cell.2021.06.004. PubMed PMID:34214472 PubMed Central PMC8329841.
- Ogishi, M, Yang, R, Aytekin, C, Langlais, D, Bourgey, M, Khan, T et al.. Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. Nat Med. 2021;27 (9):1646-1654. doi: 10.1038/s41591-021-01388-5. PubMed PMID:34183838 PubMed Central PMC8446316.
- Lin, YH, Wang, H, Fiore, A, Förster, M, Tung, LT, Belle, JI et al.. Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma. J Cell Mol Med. 2021;25 (14):7089-7094. doi: 10.1111/jcmm.16554. PubMed PMID:34114734 PubMed Central PMC8278115.
- Lin, YH, Liang, Y, Wang, H, Tung, LT, Förster, M, Subramani, PG et al.. Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1. Front Immunol. 2021;12 :626418. doi: 10.3389/fimmu.2021.626418. PubMed PMID:33912157 PubMed Central PMC8072452.
- Yang, R, Mele, F, Worley, L, Langlais, D, Rosain, J, Benhsaien, I et al.. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria. Cell. 2020;183 (7):1826-1847.e31. doi: 10.1016/j.cell.2020.10.046. PubMed PMID:33296702 PubMed Central PMC7770098.
- Belle, JI, Wang, H, Fiore, A, Petrov, JC, Lin, YH, Feng, CH et al.. MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction. JCI Insight. 2020;5 (13):. doi: 10.1172/jci.insight.125690. PubMed PMID:32641579 PubMed Central PMC7406308.
- Fiore, A, Liang, Y, Lin, YH, Tung, J, Wang, H, Langlais, D et al.. Deubiquitinase MYSM1 in the Hematopoietic System and beyond: A Current Review. Int J Mol Sci. 2020;21 (8):. doi: 10.3390/ijms21083007. PubMed PMID:32344625 PubMed Central PMC7216186.