David Langlais

David Langlais

Assistant Professor
Head, Inflammation Genomics Lab
Departments of Human Genetics and Microbiology & Immunology

Email: david.langlais@mcgill.ca
Phone: (514) 398-5844
Lab: (514) 398-5670

740 Dr Penfield Ave, Room 4203
Montréal, Québec, Canada, H3A 0G1

Website

David Langlais is an Assistant Professor in the Departments of Human Genetics and Microbiology & Immunology at McGill University, and Principal Investigator at the McGill Genome Centre. Dr Langlais completed his Ph.D. with honors in Molecular Biology in 2011 under the supervision of Dr. Jacques Drouin at the IRCM. His work revealed the complex transcriptional regulation at play in the immuno-neuroendocrine interface and in the maintenance of pituitary tissue. Dr Langlais then pursued postdoctoral research in Dr Philippe Gros’ laboratory at McGill University where he studied the role of critical innate immunity transcription factors and participated in the characterization of new proteins involved in immune function and neuroinflammatory conditions, including cerebral malaria. Dr Langlais has received multiple awards and fellowships, including the Milstein Young Investigator Award from the International Cytokine and Interferon Society and the 2018 Top 10 Discovery by Quebec Science. His current research is founded on functional genomics, bioinformatics, genome editing and molecular biology methods to explain the transcriptional mechanisms involved in normal and pathological inflammation, aiming to identify and validate novel therapeutic targets for inflammatory diseases.

Research Interests

Acute and chronic diseases of inflammation are caused by uncontrolled activation of the immune system and by ineffective return to homeostasis following insult resolution. Environmental and genetic factors are contributing to immune dysregulation. On the genetic side, not only inter-individual variations are influencing the inflammatory responses, but also the epigenetic control of gene expression by transcription factors is important.

The aim of our lab is to understand the role of transcription factors in normal and pathological inflammatory responses. We use cutting-edge molecular biology and genomics methods to:

1. Investigate the involvement of human genetic variations in chronic inflammatory diseases, such as Hashimoto thyroiditis.
2. Identify and characterize the function of transcription factors in acute and chronic inflammation.
3. Develop innovative anti-inflammatory treatments, especially to target cerebral malaria.

Recent Publications

• Ogishi, M, Kitaoka, K, Good-Jacobson, KL, Rinchai, D, Zhang, B, Wang, J et al.. Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Immunity. 2024;57 (12):2790-2807.e15. doi: 10.1016/j.immuni.2024.10.014. PubMed PMID:39603236 PubMed Central PMC11634639.
• Brizio, M, Mancini, M, Lora, M, Joy, S, Zhu, S, Brilland, B et al.. Cytokine priming enhances the antifibrotic effects of human adipose derived mesenchymal stromal cells conditioned medium. Stem Cell Res Ther. 2024;15 (1):329. doi: 10.1186/s13287-024-03916-9. PubMed PMID:39334258 PubMed Central PMC11438190.
• Kulle, A, Li, Z, Kwak, A, Mancini, M, Young, D, Avizonis, DZ et al.. Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor. Proc Natl Acad Sci U S A. 2024;121 (40):e2406294121. doi: 10.1073/pnas.2406294121. PubMed PMID:39312670 PubMed Central PMC11459156.
• Momenilandi, M, Lévy, R, Sobrino, S, Li, J, Lagresle-Peyrou, C, Esmaeilzadeh, H et al.. FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. Cell. 2024;187 (11):2817-2837.e31. doi: 10.1016/j.cell.2024.04.009. PubMed PMID:38701783 PubMed Central PMC11149630.
• Tandoh, KZ, Ibarra-Meneses, AV, Langlais, D, Olivier, M, Torrecilhas, AC, Fernandez-Prada, C et al.. Extracellular Vesicles: Translational Agenda Questions for Three Protozoan Parasites. Traffic. 2024;25 (4):e12935. doi: 10.1111/tra.12935. PubMed PMID:38629580 .
• Guérin, A, Moncada-Vélez, M, Jackson, K, Ogishi, M, Rosain, J, Mancini, M et al.. Helper T cell immunity in humans with inherited CD4 deficiency. J Exp Med. 2024;221 (5):. doi: 10.1084/jem.20231044. PubMed PMID:38557723 PubMed Central PMC10983808.
• Liang, Y, Wang, H, Seija, N, Lin, YH, Tung, LT, Di Noia, JM et al.. B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1. Front Immunol. 2024;15 :1353138. doi: 10.3389/fimmu.2024.1353138. PubMed PMID:38529289 PubMed Central PMC10961346.
• Materna, M, Delmonte, OM, Bosticardo, M, Momenilandi, M, Conrey, PE, Charmeteau-De Muylder, B et al.. The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants. Science. 2024;383 (6686):eadh4059. doi: 10.1126/science.adh4059. PubMed PMID:38422122 PubMed Central PMC10958617.
• Mousa, M, Liang, Y, Tung, LT, Wang, H, Krawczyk, C, Langlais, D et al.. Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation. Immunology. 2024;172 (1):109-126. doi: 10.1111/imm.13758. PubMed PMID:38316548 .
• Olivier, JF, Langlais, D, Jeyakumar, T, Polyak, MJ, Galarneau, L, Cayrol, R et al.. CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitis. Commun Biol. 2024;7 (1):77. doi: 10.1038/s42003-023-05751-9. PubMed PMID:38200184 PubMed Central PMC10781698.