Head, Inflammation Genomics Lab
Departments of Human Genetics and Microbiology & Immunology
Phone: (514) 398-5844
Lab: (514) 398-5670
740 Dr Penfield Ave, Room 4203
Montréal, Québec, Canada, H3A 0G1
David Langlais is an Assistant Professor in the Departments of Human Genetics and Microbiology & Immunology at McGill University, and Principal Investigator at the McGill Genome Centre. Dr Langlais completed his Ph.D. with honors in Molecular Biology in 2011 under the supervision of Dr. Jacques Drouin at the IRCM. His work revealed the complex transcriptional regulation at play in the immuno-neuroendocrine interface and in the maintenance of pituitary tissue. Dr Langlais then pursued postdoctoral research in Dr Philippe Gros’ laboratory at McGill University where he studied the role of critical innate immunity transcription factors and participated in the characterization of new proteins involved in immune function and neuroinflammatory conditions, including cerebral malaria. Dr Langlais has received multiple awards and fellowships, including the Milstein Young Investigator Award from the International Cytokine and Interferon Society and the 2018 Top 10 Discovery by Quebec Science. His current research is founded on functional genomics, bioinformatics, genome editing and molecular biology methods to explain the transcriptional mechanisms involved in normal and pathological inflammation, aiming to identify and validate novel therapeutic targets for inflammatory diseases.
Acute and chronic diseases of inflammation are caused by uncontrolled activation of the immune system and by ineffective return to homeostasis following insult resolution. Environmental and genetic factors are contributing to immune dysregulation. On the genetic side, not only inter-individual variations are influencing the inflammatory responses, but also the epigenetic control of gene expression by transcription factors is important.
The aim of our lab is to understand the role of transcription factors in normal and pathological inflammatory responses. We use cutting-edge molecular biology and genomics methods to:
- Investigate the involvement of human genetic variations in chronic inflammatory diseases, such as Hashimoto thyroiditis.
- Identify and characterize the function of transcription factors in acute and chronic inflammation.
- Develop innovative anti-inflammatory treatments, especially to target cerebral malaria.
- Yang, R, Mele, F, Worley, L, Langlais, D, Rosain, J, Benhsaien, I et al.. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria. Cell. 2020;183 (7):1826-1847.e31. doi: 10.1016/j.cell.2020.10.046. PubMed PMID:33296702 PubMed Central PMC7770098.
- Belle, JI, Wang, H, Fiore, A, Petrov, JC, Lin, YH, Feng, CH et al.. MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction. JCI Insight. 2020;5 (13):. doi: 10.1172/jci.insight.125690. PubMed PMID:32641579 PubMed Central PMC7406308.
- Fiore, A, Liang, Y, Lin, YH, Tung, J, Wang, H, Langlais, D et al.. Deubiquitinase MYSM1 in the Hematopoietic System and beyond: A Current Review. Int J Mol Sci. 2020;21 (8):. doi: 10.3390/ijms21083007. PubMed PMID:32344625 PubMed Central PMC7216186.
- Jeyakumar, T, Fodil, N, Van Der Kraak, L, Meunier, C, Cayrol, R, McGregor, K et al.. Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer. Sci Rep. 2019;9 (1):18897. doi: 10.1038/s41598-019-55378-2. PubMed PMID:31827213 PubMed Central PMC6906452.
- Kennedy, JM, Georges, A, Bassenden, AV, Vidal, SM, Berghuis, AM, Taniuchi, I et al.. ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis. Infect Immun. 2020;88 (2):. doi: 10.1128/IAI.00845-19. PubMed PMID:31792077 PubMed Central PMC6977123.
- Lin, YH, Forster, M, Liang, Y, Yu, M, Wang, H, Robert, F et al.. USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model. Exp Hematol. 2019;72 :1-8. doi: 10.1016/j.exphem.2019.01.001. PubMed PMID:30639577 .
- Kong, XF, Martinez-Barricarte, R, Kennedy, J, Mele, F, Lazarov, T, Deenick, EK et al.. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 2018;19 (9):973-985. doi: 10.1038/s41590-018-0178-z. PubMed PMID:30127434 PubMed Central PMC6130844.
- Torre, S, Langlais, D, Gros, P. Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei. Mamm Genome. 2018;29 (7-8):488-506. doi: 10.1007/s00335-018-9752-9. PubMed PMID:29922917 .
- Langlais, D, Cencic, R, Moradin, N, Kennedy, JM, Ayi, K, Brown, LE et al.. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proc Natl Acad Sci U S A. 2018;115 (10):E2366-E2375. doi: 10.1073/pnas.1713000115. PubMed PMID:29463745 PubMed Central PMC5877959.
- Rojo, R, Pridans, C, Langlais, D, Hume, DA. Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus. Clin Sci (Lond). 2017;131 (16):2161-2182. doi: 10.1042/CS20170238. PubMed PMID:28760770 .