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Marc Dumas

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Marc Dumas

Professor, Department of Human Genetics

Email:
Phone: (514) 398-8602
Fax: (514) 398-1790

Website

Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Liew, F, Talwar, S, Cross, A, Willett, BJ, Scott, S, Logan, N et al.. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBioMedicine. 2023;87 :104402. doi: 10.1016/j.ebiom.2022.104402. PubMed PMID:36543718 PubMed Central PMC9762734.
  • Vink, E, Davis, C, MacLean, A, Pascall, D, McDonald, SE, Gunson, R et al.. Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. Open Forum Infect Dis. 2022;9 (11):ofac531. doi: 10.1093/ofid/ofac531. PubMed PMID:36381618 PubMed Central PMC9619746.
  • Wu, V, Tillner, J, Jones, E, McKenzie, JS, Gurung, D, Mroz, A et al.. High Resolution Ambient MS Imaging of Biological Samples by Desorption Electro-Flow Focussing Ionization. Anal Chem. 2022;94 (28):10035-10044. doi: 10.1021/acs.analchem.2c00345. PubMed PMID:35786855 PubMed Central PMC9310024.
  • Serger, E, Luengo-Gutierrez, L, Chadwick, JS, Kong, G, Zhou, L, Crawford, G et al.. The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature. 2022;607 (7919):585-592. doi: 10.1038/s41586-022-04884-x. PubMed PMID:35732737 .
  • Närhi, F, Moonesinghe, SR, Shenkin, SD, Drake, TM, Mulholland, RH, Donegan, C et al.. Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. Lancet Digit Health. 2022;4 (4):e220-e234. doi: 10.1016/S2589-7500(22)00018-8. PubMed PMID:35337642 PubMed Central PMC8940185.
  • Fromentin, S, Forslund, SK, Chechi, K, Aron-Wisnewsky, J, Chakaroun, R, Nielsen, T et al.. Microbiome and metabolome features of the cardiometabolic disease spectrum. Nat Med. 2022;28 (2):303-314. doi: 10.1038/s41591-022-01688-4. PubMed PMID:35177860 PubMed Central PMC8863577.
  • Talmor-Barkan, Y, Bar, N, Shaul, AA, Shahaf, N, Godneva, A, Bussi, Y et al.. Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Nat Med. 2022;28 (2):295-302. doi: 10.1038/s41591-022-01686-6. PubMed PMID:35177859 .
  • Menghini, R, Hoyles, L, Cardellini, M, Casagrande, V, Marino, A, Gentileschi, P et al.. ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids. Mol Metab. 2022;59 :101454. doi: 10.1016/j.molmet.2022.101454. PubMed PMID:35150905 PubMed Central PMC8886057.
  • Dejnirattisai, W, Huo, J, Zhou, D, Zahradník, J, Supasa, P, Liu, C et al.. SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell. 2022;185 (3):467-484.e15. doi: 10.1016/j.cell.2021.12.046. PubMed PMID:35081335 PubMed Central PMC8723827.
  • Belda, E, Voland, L, Tremaroli, V, Falony, G, Adriouch, S, Assmann, KE et al.. Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. Gut. 2022;71 (12):2463-2480. doi: 10.1136/gutjnl-2021-325753. PubMed PMID:35017197 PubMed Central PMC9664128.
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