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Marc Dumas

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Marc Dumas

Professor, Department of Human Genetics

Email:
Phone: (514) 398-8602
Fax: (514) 398-1790

Website

Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Serger, E, Luengo-Gutierrez, L, Chadwick, JS, Kong, G, Zhou, L, Crawford, G et al.. The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature. 2022; :. doi: 10.1038/s41586-022-04884-x. PubMed PMID:35732737 .
  • Närhi, F, Moonesinghe, SR, Shenkin, SD, Drake, TM, Mulholland, RH, Donegan, C et al.. Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. Lancet Digit Health. 2022;4 (4):e220-e234. doi: 10.1016/S2589-7500(22)00018-8. PubMed PMID:35337642 PubMed Central PMC8940185.
  • Fromentin, S, Forslund, SK, Chechi, K, Aron-Wisnewsky, J, Chakaroun, R, Nielsen, T et al.. Microbiome and metabolome features of the cardiometabolic disease spectrum. Nat Med. 2022;28 (2):303-314. doi: 10.1038/s41591-022-01688-4. PubMed PMID:35177860 PubMed Central PMC8863577.
  • Talmor-Barkan, Y, Bar, N, Shaul, AA, Shahaf, N, Godneva, A, Bussi, Y et al.. Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Nat Med. 2022;28 (2):295-302. doi: 10.1038/s41591-022-01686-6. PubMed PMID:35177859 .
  • Menghini, R, Hoyles, L, Cardellini, M, Casagrande, V, Marino, A, Gentileschi, P et al.. ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids. Mol Metab. 2022;59 :101454. doi: 10.1016/j.molmet.2022.101454. PubMed PMID:35150905 PubMed Central PMC8886057.
  • Dejnirattisai, W, Huo, J, Zhou, D, Zahradník, J, Supasa, P, Liu, C et al.. SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. Cell. 2022;185 (3):467-484.e15. doi: 10.1016/j.cell.2021.12.046. PubMed PMID:35081335 PubMed Central PMC8723827.
  • Belda, E, Voland, L, Tremaroli, V, Falony, G, Adriouch, S, Assmann, KE et al.. Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. Gut. 2022; :. doi: 10.1136/gutjnl-2021-325753. PubMed PMID:35017197 .
  • Norris, T, Razieh, C, Zaccardi, F, Yates, T, Islam, N, Gillies, CL et al.. Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. Heart. 2021; :. doi: 10.1136/heartjnl-2021-320047. PubMed PMID:34911741 PubMed Central PMC8678560.
  • Forslund, SK, Chakaroun, R, Zimmermann-Kogadeeva, M, Markó, L, Aron-Wisnewsky, J, Nielsen, T et al.. Combinatorial, additive and dose-dependent drug-microbiome associations. Nature. 2021;600 (7889):500-505. doi: 10.1038/s41586-021-04177-9. PubMed PMID:34880489 .
  • Nalpas, N, Hoyles, L, Anselm, V, Ganief, T, Martinez-Gili, L, Grau, C et al.. An integrated workflow for enhanced taxonomic and functional coverage of the mouse fecal metaproteome. Gut Microbes. ;13 (1):1994836. doi: 10.1080/19490976.2021.1994836. PubMed PMID:34763597 PubMed Central PMC8726736.
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