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Marc Dumas

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Marc Dumas

Professor, Department of Human Genetics

Email:
Phone: (514) 398-8602
Fax: (514) 398-1790

Website

Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Cuthbertson, L, Löber, U, Ish-Horowicz, JS, McBrien, CN, Churchward, C, Parker, JC et al.. Genomic attributes of airway commensal bacteria and mucosa. Commun Biol. 2024;7 (1):171. doi: 10.1038/s42003-024-05840-3. PubMed PMID:38347162 PubMed Central PMC10861553.
  • Michael, BD, Dunai, C, Needham, EJ, Tharmaratnam, K, Williams, R, Huang, Y et al.. Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nat Commun. 2023;14 (1):8487. doi: 10.1038/s41467-023-42320-4. PubMed PMID:38135686 PubMed Central PMC10746705.
  • Sidhu, JK, Siggins, MK, Liew, F, Russell, CD, Uruchurtu, ASS, Davis, C et al.. Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19. J Infect Dis. 2023; :. doi: 10.1093/infdis/jiad590. PubMed PMID:38134401 .
  • Quesada-Vázquez, S, Castells-Nobau, A, Latorre, J, Oliveras-Cañellas, N, Puig-Parnau, I, Tejera, N et al.. Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity. Cell Rep Med. 2023;4 (12):101341. doi: 10.1016/j.xcrm.2023.101341. PubMed PMID:38118419 PubMed Central PMC10772641.
  • Andrikopoulos, P, Aron-Wisnewsky, J, Chakaroun, R, Myridakis, A, Forslund, SK, Nielsen, T et al.. Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. Nat Commun. 2023;14 (1):5843. doi: 10.1038/s41467-023-39824-4. PubMed PMID:37730687 PubMed Central PMC10511707.
  • Roper, KJ, Thomas, J, Albalawi, W, Maddocks, E, Dobson, S, Alshehri, A et al.. Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera. Sci Rep. 2023;13 (1):15014. doi: 10.1038/s41598-023-41928-2. PubMed PMID:37697014 PubMed Central PMC10495436.
  • Zhu, Y, Almeida, FJ, Baillie, JK, Bowen, AC, Britton, PN, Brizuela, ME et al.. International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA Pediatr. 2023;177 (10):1073-1084. doi: 10.1001/jamapediatrics.2023.3117. PubMed PMID:37603343 PubMed Central PMC10442787.
  • Pairo-Castineira, E, Rawlik, K, Bretherick, AD, Qi, T, Wu, Y, Nassiri, I et al.. Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;619 (7971):E61. doi: 10.1038/s41586-023-06383-z. PubMed PMID:37433877 PubMed Central PMC10371859.
  • Pairo-Castineira, E, Rawlik, K, Bretherick, AD, Qi, T, Wu, Y, Nassiri, I et al.. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;617 (7962):764-768. doi: 10.1038/s41586-023-06034-3. PubMed PMID:37198478 PubMed Central PMC10208981.
  • Molinaro, A, Nemet, I, Bel Lassen, P, Chakaroun, R, Nielsen, T, Aron-Wisnewsky, J et al.. Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality. JACC Heart Fail. 2023;11 (7):810-821. doi: 10.1016/j.jchf.2023.03.008. PubMed PMID:37115134 .
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