Marc Dumas
Professor, Department of Human Genetics
Email:
Phone: (514) 398-8602
Fax: (514) 398-1790
Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer. He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.
Recent Publications
- Callaby, H, Olver, J, Emery, K, Richards, KS, Killip, M, Groves, N et al.. Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients. Lancet Infect Dis. 2024; :. doi: 10.1016/S1473-3099(24)00735-7. PubMed PMID:39617024 .
- Castells-Nobau, A, Moreno-Navarrete, JM, de la Vega-Correa, L, Puig, I, Federici, M, Sun, J et al.. Multiomics of the intestine-liver-adipose axis in multiple studies unveils a consistent link of the gut microbiota and the antiviral response with systemic glucose metabolism. Gut. 2024; :. doi: 10.1136/gutjnl-2024-332602. PubMed PMID:39358003 .
- Sidhu, JK, Siggins, MK, Liew, F, Russell, CD, Uruchurtu, ASS, Davis, C et al.. Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19. J Infect Dis. 2024;230 (1):e17-e29. doi: 10.1093/infdis/jiad590. PubMed PMID:39052740 PubMed Central PMC11272059.
- Liew, F, Efstathiou, C, Fontanella, S, Richardson, M, Saunders, R, Swieboda, D et al.. Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. Nat Immunol. 2024;25 (4):607-621. doi: 10.1038/s41590-024-01778-0. PubMed PMID:38589621 PubMed Central PMC11003868.
- Michael, BD, Dunai, C, Needham, EJ, Tharmaratnam, K, Williams, R, Huang, Y et al.. Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nat Commun. 2024;15 (1):2918. doi: 10.1038/s41467-024-47320-6. PubMed PMID:38575615 PubMed Central PMC10995197.
- Cuthbertson, L, Löber, U, Ish-Horowicz, JS, McBrien, CN, Churchward, C, Parker, JC et al.. Genomic attributes of airway commensal bacteria and mucosa. Commun Biol. 2024;7 (1):171. doi: 10.1038/s42003-024-05840-3. PubMed PMID:38347162 PubMed Central PMC10861553.
- Michael, BD, Dunai, C, Needham, EJ, Tharmaratnam, K, Williams, R, Huang, Y et al.. Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nat Commun. 2023;14 (1):8487. doi: 10.1038/s41467-023-42320-4. PubMed PMID:38135686 PubMed Central PMC10746705.
- Quesada-Vázquez, S, Castells-Nobau, A, Latorre, J, Oliveras-Cañellas, N, Puig-Parnau, I, Tejera, N et al.. Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity. Cell Rep Med. 2023;4 (12):101341. doi: 10.1016/j.xcrm.2023.101341. PubMed PMID:38118419 PubMed Central PMC10772641.
- Andrikopoulos, P, Aron-Wisnewsky, J, Chakaroun, R, Myridakis, A, Forslund, SK, Nielsen, T et al.. Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. Nat Commun. 2023;14 (1):5843. doi: 10.1038/s41467-023-39824-4. PubMed PMID:37730687 PubMed Central PMC10511707.
- Roper, KJ, Thomas, J, Albalawi, W, Maddocks, E, Dobson, S, Alshehri, A et al.. Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera. Sci Rep. 2023;13 (1):15014. doi: 10.1038/s41598-023-41928-2. PubMed PMID:37697014 PubMed Central PMC10495436.