Marc Dumas
Professor, Department of Human Genetics
Email:
Phone: (514) 398-8602
Fax: (514) 398-1790
Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer. He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.
Recent Publications
- Andrikopoulos, P, Aron-Wisnewsky, J, Chakaroun, R, Myridakis, A, Forslund, SK, Nielsen, T et al.. Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. Nat Commun. 2023;14 (1):5843. doi: 10.1038/s41467-023-39824-4. PubMed PMID:37730687 PubMed Central PMC10511707.
- Roper, KJ, Thomas, J, Albalawi, W, Maddocks, E, Dobson, S, Alshehri, A et al.. Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera. Sci Rep. 2023;13 (1):15014. doi: 10.1038/s41598-023-41928-2. PubMed PMID:37697014 PubMed Central PMC10495436.
- Zhu, Y, Almeida, FJ, Baillie, JK, Bowen, AC, Britton, PN, Brizuela, ME et al.. International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA Pediatr. 2023;177 (10):1073-1084. doi: 10.1001/jamapediatrics.2023.3117. PubMed PMID:37603343 PubMed Central PMC10442787.
- Pairo-Castineira, E, Rawlik, K, Bretherick, AD, Qi, T, Wu, Y, Nassiri, I et al.. Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;619 (7971):E61. doi: 10.1038/s41586-023-06383-z. PubMed PMID:37433877 PubMed Central PMC10371859.
- Pairo-Castineira, E, Rawlik, K, Bretherick, AD, Qi, T, Wu, Y, Nassiri, I et al.. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;617 (7962):764-768. doi: 10.1038/s41586-023-06034-3. PubMed PMID:37198478 PubMed Central PMC10208981.
- Molinaro, A, Nemet, I, Bel Lassen, P, Chakaroun, R, Nielsen, T, Aron-Wisnewsky, J et al.. Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality. JACC Heart Fail. 2023;11 (7):810-821. doi: 10.1016/j.jchf.2023.03.008. PubMed PMID:37115134 .
- Graham, NSN, Blissitt, G, Zimmerman, K, Friedland, D, Dumas, ME, Coady, E et al.. ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 - a longitudinal cohort study. BMJ Open. 2023;13 (3):e069243. doi: 10.1136/bmjopen-2022-069243. PubMed PMID:36944467 PubMed Central PMC10032415.
- Goldswain, H, Dong, X, Penrice-Randal, R, Alruwaili, M, Shawli, GT, Prince, T et al.. The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection. Genome Biol. 2023;24 (1):47. doi: 10.1186/s13059-023-02881-5. PubMed PMID:36915185 PubMed Central PMC10009825.
- Liew, F, Talwar, S, Cross, A, Willett, BJ, Scott, S, Logan, N et al.. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBioMedicine. 2023;87 :104402. doi: 10.1016/j.ebiom.2022.104402. PubMed PMID:36543718 PubMed Central PMC9762734.
- Vink, E, Davis, C, MacLean, A, Pascall, D, McDonald, SE, Gunson, R et al.. Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. Open Forum Infect Dis. 2022;9 (11):ofac531. doi: 10.1093/ofid/ofac531. PubMed PMID:36381618 PubMed Central PMC9619746.