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Marc Dumas

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Marc Dumas

Professor, Department of Human Genetics

Email:
Phone: (514) 398-8602
Fax: (514) 398-1790

Website

Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Vieira-Silva, S, Falony, G, Belda, E, Nielsen, T, Aron-Wisnewsky, J, Chakaroun, R et al.. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature. 2020;581 (7808):310-315. doi: 10.1038/s41586-020-2269-x. PubMed PMID:32433607 .
  • Mayneris-Perxachs, J, Puig, J, Burcelin, R, Dumas, ME, Barton, RH, Hoyles, L et al.. The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients. Clin Nutr. 2020; :. doi: 10.1016/j.clnu.2020.02.034. PubMed PMID:32199697 .
  • Péan, N, Le Lay, A, Brial, F, Wasserscheid, J, Rouch, C, Vincent, M et al.. Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. Diabetologia. 2020;63 (6):1223-1235. doi: 10.1007/s00125-020-05122-7. PubMed PMID:32173762 PubMed Central PMC7228998.
  • Brial, F, Alzaid, F, Sonomura, K, Kamatani, Y, Meneyrol, K, Le Lay, A et al.. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Rep. 2020;30 (7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066. PubMed PMID:32075738 .
  • Abdul Rahim, MBH, Chilloux, J, Martinez-Gili, L, Neves, AL, Myridakis, A, Gooderham, N et al.. Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles. Acta Diabetol. 2019;56 (5):493-500. doi: 10.1007/s00592-019-01312-x. PubMed PMID:30903435 PubMed Central PMC6451719.
  • Brial, F, Le Lay, A, Hedjazi, L, Tsang, T, Fearnside, JF, Otto, GW et al.. Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment. Sci Rep. 2019;9 (1):3656. doi: 10.1038/s41598-019-40153-0. PubMed PMID:30842494 PubMed Central PMC6403227.
  • Dao, MC, Sokolovska, N, Brazeilles, R, Affeldt, S, Pelloux, V, Prifti, E et al.. A Data Integration Multi-Omics Approach to Study Calorie Restriction-Induced Changes in Insulin Sensitivity. 2018;9 :1958. doi: 10.3389/fphys.2018.01958. PubMed PMID:30804813 PubMed Central PMC6371001.
  • Zalloua, P, Kadar, H, Hariri, E, Abi Farraj, L, Brial, F, Hedjazi, L et al.. Untargeted Mass Spectrometry Lipidomics identifies correlation between serum sphingomyelins and plasma cholesterol. Lipids Health Dis. 2019;18 (1):38. doi: 10.1186/s12944-018-0948-5. PubMed PMID:30711004 PubMed Central PMC6359757.
  • Leboucher, A, Pisani, DF, Martinez-Gili, L, Chilloux, J, Bermudez-Martin, P, Van Dijck, A et al.. The translational regulator FMRP controls lipid and glucose metabolism in mice and humans. Mol Metab. 2019;21 :22-35. doi: 10.1016/j.molmet.2019.01.002. PubMed PMID:30686771 PubMed Central PMC6407369.
  • Rodriguez-Martinez, A, Ayala, R, Posma, JM, Harvey, N, Jiménez, B, Sonomura, K et al.. pJRES Binning Algorithm (JBA): a new method to facilitate the recovery of metabolic information from pJRES 1H NMR spectra. Bioinformatics. 2019;35 (11):1916-1922. doi: 10.1093/bioinformatics/bty837. PubMed PMID:30351417 PubMed Central PMC6546129.
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