Marc Dumas

Home / Investigators  / Marc Dumas

Marc Dumas

Professor, Department of Human Genetics

Phone: (514) 398-8602
Fax: (514) 398-1790


Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Pairo-Castineira, E, Rawlik, K, Bretherick, AD, Qi, T, Wu, Y, Nassiri, I et al.. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;617 (7962):764-768. doi: 10.1038/s41586-023-06034-3. PubMed PMID:37198478 PubMed Central PMC10208981.
  • Graham, NSN, Blissitt, G, Zimmerman, K, Friedland, D, Dumas, ME, Coady, E et al.. ADVANCE-TBI study protocol: traumatic brain injury outcomes in UK military personnel serving in Afghanistan between 2003 and 2014 - a longitudinal cohort study. BMJ Open. 2023;13 (3):e069243. doi: 10.1136/bmjopen-2022-069243. PubMed PMID:36944467 PubMed Central PMC10032415.
  • Goldswain, H, Dong, X, Penrice-Randal, R, Alruwaili, M, Shawli, GT, Prince, T et al.. The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection. Genome Biol. 2023;24 (1):47. doi: 10.1186/s13059-023-02881-5. PubMed PMID:36915185 PubMed Central PMC10009825.
  • Liew, F, Talwar, S, Cross, A, Willett, BJ, Scott, S, Logan, N et al.. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBioMedicine. 2023;87 :104402. doi: 10.1016/j.ebiom.2022.104402. PubMed PMID:36543718 PubMed Central PMC9762734.
  • Vink, E, Davis, C, MacLean, A, Pascall, D, McDonald, SE, Gunson, R et al.. Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. Open Forum Infect Dis. 2022;9 (11):ofac531. doi: 10.1093/ofid/ofac531. PubMed PMID:36381618 PubMed Central PMC9619746.
  • Wu, V, Tillner, J, Jones, E, McKenzie, JS, Gurung, D, Mroz, A et al.. High Resolution Ambient MS Imaging of Biological Samples by Desorption Electro-Flow Focussing Ionization. Anal Chem. 2022;94 (28):10035-10044. doi: 10.1021/acs.analchem.2c00345. PubMed PMID:35786855 PubMed Central PMC9310024.
  • Serger, E, Luengo-Gutierrez, L, Chadwick, JS, Kong, G, Zhou, L, Crawford, G et al.. The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature. 2022;607 (7919):585-592. doi: 10.1038/s41586-022-04884-x. PubMed PMID:35732737 .
  • Närhi, F, Moonesinghe, SR, Shenkin, SD, Drake, TM, Mulholland, RH, Donegan, C et al.. Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. Lancet Digit Health. 2022;4 (4):e220-e234. doi: 10.1016/S2589-7500(22)00018-8. PubMed PMID:35337642 PubMed Central PMC8940185.
  • Fromentin, S, Forslund, SK, Chechi, K, Aron-Wisnewsky, J, Chakaroun, R, Nielsen, T et al.. Microbiome and metabolome features of the cardiometabolic disease spectrum. Nat Med. 2022;28 (2):303-314. doi: 10.1038/s41591-022-01688-4. PubMed PMID:35177860 PubMed Central PMC8863577.
  • Talmor-Barkan, Y, Bar, N, Shaul, AA, Shahaf, N, Godneva, A, Bussi, Y et al.. Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease. Nat Med. 2022;28 (2):295-302. doi: 10.1038/s41591-022-01686-6. PubMed PMID:35177859 .
Search PubMed