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Marc Dumas

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Marc Dumas

Professor, Department of Human Genetics

Email:
Phone: (514) 398-8602
Fax: (514) 398-1790

Website

Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Belda, E, Voland, L, Tremaroli, V, Falony, G, Adriouch, S, Assmann, KE et al.. Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. Gut. 2022; :. doi: 10.1136/gutjnl-2021-325753. PubMed PMID:35017197 .
  • Norris, T, Razieh, C, Zaccardi, F, Yates, T, Islam, N, Gillies, CL et al.. Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. Heart. 2021; :. doi: 10.1136/heartjnl-2021-320047. PubMed PMID:34911741 PubMed Central PMC8678560.
  • Forslund, SK, Chakaroun, R, Zimmermann-Kogadeeva, M, Markó, L, Aron-Wisnewsky, J, Nielsen, T et al.. Combinatorial, additive and dose-dependent drug-microbiome associations. Nature. 2021;600 (7889):500-505. doi: 10.1038/s41586-021-04177-9. PubMed PMID:34880489 .
  • Nalpas, N, Hoyles, L, Anselm, V, Ganief, T, Martinez-Gili, L, Grau, C et al.. An integrated workflow for enhanced taxonomic and functional coverage of the mouse fecal metaproteome. Gut Microbes. ;13 (1):1994836. doi: 10.1080/19490976.2021.1994836. PubMed PMID:34763597 PubMed Central PMC8726736.
  • de Silva, TI, Liu, G, Lindsey, BB, Dong, D, Moore, SC, Hsu, NS et al.. The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience. 2021;24 (11):103353. doi: 10.1016/j.isci.2021.103353. PubMed PMID:34729465 PubMed Central PMC8552693.
  • Nuzzo, A, Guedj, K, Curac, S, Hercend, C, Bendavid, C, Gault, N et al.. Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia. Sci Rep. 2021;11 (1):18929. doi: 10.1038/s41598-021-98012-w. PubMed PMID:34556697 PubMed Central PMC8460675.
  • Drake, TM, Riad, AM, Fairfield, CJ, Egan, C, Knight, SR, Pius, R et al.. Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. Lancet. 2021;398 (10296):223-237. doi: 10.1016/S0140-6736(21)00799-6. PubMed PMID:34274064 PubMed Central PMC8285118.
  • Bermudez-Martin, P, Becker, JAJ, Caramello, N, Fernandez, SP, Costa-Campos, R, Canaguier, J et al.. The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome. 2021;9 (1):157. doi: 10.1186/s40168-021-01103-z. PubMed PMID:34238386 PubMed Central PMC8268286.
  • COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature. 2021;600 (7889):472-477. doi: 10.1038/s41586-021-03767-x. PubMed PMID:34237774 PubMed Central PMC8674144.
  • Brial, F, Chilloux, J, Nielsen, T, Vieira-Silva, S, Falony, G, Andrikopoulos, P et al.. Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut. 2021;70 (11):2105-2114. doi: 10.1136/gutjnl-2020-323314. PubMed PMID:33975870 PubMed Central PMC8515120.
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