Associate Professor, Department of Microbiology and Immunology
740 Dr Penfield Ave, Room 7006
Montréal, Québec, Canada, H3A 0G1
Jesse Shapiro did his undergrad in Biology at McGill, followed by an MSc in Integrative Bioscience at Oxford. He then completed a PhD in Computational and Systems Biology at MIT with Eric Alm, where he developed methods to detect signatures of natural selection, recombination, and speciation in bacterial genomes. He went on to a postdoc with Pardis Sabeti at the Broad Institute and Harvard University, where he studied the evolutionary genomics of Mycobacterium tuberculosis and Lassa virus. After seven years as Canada Research Chair in Microbial Evolutionary Genomics at Université de Montréal, he returned to McGill as an associate professor in the Department of Microbiology and Immunology and the Genome Centre.
Jesse’s research uses genomics to understand the ecology and evolution of microbes, ranging from freshwater bacterioplankton to the human gut microbiome. His work has helped elucidate the origins of bacterial species, leading to a more unified species concept across domains of life, and has developed genome-wide association study (GWAS) methods tailored for bacteria. He is particularly interested in pathogen evolution, and their evolution within patients, and interactions with members of the resident microbiome. His laboratory currently has projects on the ecology and evolution of toxic cyanobacterial blooms, cholera infections, and antimicrobial resistance, among others.
- Douglas, GM, Shapiro, BJ. Genic selection within prokaryotic pangenomes. Genome Biol Evol. 2021; :. doi: 10.1093/gbe/evab234. PubMed PMID:34665261 .
- Pérez-Carrascal, OM, Tromas, N, Terrat, Y, Moreno, E, Giani, A, Corrêa Braga Marques, L et al.. Single-colony sequencing reveals microbe-by-microbiome phylosymbiosis between the cyanobacterium Microcystis and its associated bacteria. Microbiome. 2021;9 (1):194. doi: 10.1186/s40168-021-01140-8. PubMed PMID:34579777 PubMed Central PMC8477515.
- Levade, I, Khan, AI, Chowdhury, F, Calderwood, SB, Ryan, ET, Harris, JB et al.. A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients. mSystems. 2021;6 (4):e0088921. doi: 10.1128/mSystems.00889-21. PubMed PMID:34427503 PubMed Central PMC8407408.
- Orsi, WD, Magritsch, T, Vargas, S, Coskun, ÖK, Vuillemin, A, Höhna, S et al.. Genome Evolution in Bacteria Isolated from Million-Year-Old Subseafloor Sediment. mBio. 2021;12 (4):e0115021. doi: 10.1128/mBio.01150-21. PubMed PMID:34399613 PubMed Central PMC8406185.
- Barbosa da Costa, N, Fugère, V, Hébert, MP, Xu, CCY, Barrett, RDH, Beisner, BE et al.. Resistance, resilience, and functional redundancy of freshwater bacterioplankton communities facing a gradient of agricultural stressors in a mesocosm experiment. Mol Ecol. 2021;30 (19):4771-4788. doi: 10.1111/mec.16100. PubMed PMID:34324752 .
- Hébert, MP, Fugère, V, Beisner, BE, Barbosa da Costa, N, Barrett, RDH, Bell, G et al.. Widespread agrochemicals differentially affect zooplankton biomass and community structure. Ecol Appl. 2021;31 (7):e02423. doi: 10.1002/eap.2423. PubMed PMID:34288209 .
- N'Guessan, A, Brito, IL, Serohijos, AWR, Shapiro, BJ. Mobile Gene Sequence Evolution within Individual Human Gut Microbiomes Is Better Explained by Gene-Specific Than Host-Specific Selective Pressures. Genome Biol Evol. 2021;13 (8):. doi: 10.1093/gbe/evab142. PubMed PMID:34132784 PubMed Central PMC8358218.
- Soto, JC, Barakat, M, Hutter, JA, Kiely, M, Moreira, S, Shapiro, BJ et al.. Outbreak investigation of SARS-CoV-2 transmission in an emergency childcare centre. Can J Public Health. 2021;112 (4):566-575. doi: 10.17269/s41997-021-00544-1. PubMed PMID:34047966 PubMed Central PMC8161718.
- Groussin, M, Poyet, M, Sistiaga, A, Kearney, SM, Moniz, K, Noel, M et al.. Elevated rates of horizontal gene transfer in the industrialized human microbiome. Cell. 2021;184 (8):2053-2067.e18. doi: 10.1016/j.cell.2021.02.052. PubMed PMID:33794144 .
- Taguer, M, Shapiro, BJ, Maurice, CF. Translational activity is uncoupled from nucleic acid content in bacterial cells of the human gut microbiota. Gut Microbes. ;13 (1):1-15. doi: 10.1080/19490976.2021.1903289. PubMed PMID:33779505 PubMed Central PMC8009119.