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Jesse Shapiro

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Jesse Shapiro

Associate Professor, Department of Microbiology and Immunology

Email: jesse.shapiro@umontreal.ca
Phone: TBA

740 Dr Penfield Ave, Room 7006
Montréal, Québec, Canada, H3A 0G1

Website

Jesse Shapiro did his undergrad in Biology at McGill, followed by an MSc in Integrative Bioscience at Oxford. He then completed a PhD in Computational and Systems Biology at MIT with Eric Alm, where he developed methods to detect signatures of natural selection, recombination, and speciation in bacterial genomes. He went on to a postdoc with Pardis Sabeti at the Broad Institute and Harvard University, where he studied the evolutionary genomics of Mycobacterium tuberculosis and Lassa virus. After seven years as Canada Research Chair in Microbial Evolutionary Genomics at Université de Montréal, he returned to McGill as an associate professor in the Department of Microbiology and Immunology and the Genome Centre. 

Research Interests

Jesse’s research uses genomics to understand the ecology and evolution of microbes, ranging from freshwater bacterioplankton to the human gut microbiome. His work has helped elucidate the origins of bacterial species, leading to a more unified species concept across domains of life, and has developed genome-wide association study (GWAS) methods tailored for bacteria. He is particularly interested in pathogen evolution, and their evolution within patients, and interactions with members of the resident  microbiome. His laboratory currently has projects on the ecology and evolution of toxic cyanobacterial blooms, cholera infections, and antimicrobial resistance, among others.

Recent Publications

  • Lypaczewski, P, Chac, D, Dunmire, CN, Tandoc, KM, Chowdhury, F, Khan, AI et al.. Vibrio cholerae O1 experiences mild bottlenecks through the gastrointestinal tract in some but not all cholera patients. Microbiol Spectr. 2024; :e0078524. doi: 10.1128/spectrum.00785-24. PubMed PMID:38916318 .
  • Sutcliffe, SG, Kraemer, SA, Ellmen, I, Knapp, JJ, Overton, AK, Nash, D et al.. Tracking SARS-CoV-2 variants of concern in wastewater: an assessment of nine computational tools using simulated genomic data. Microb Genom. 2024;10 (5):. doi: 10.1099/mgen.0.001249. PubMed PMID:38785221 PubMed Central PMC11165662.
  • Gill, EE, Jia, B, Murall, CL, Poujol, R, Anwar, MZ, John, NS et al.. The Canadian VirusSeq Data Portal & Duotang: open resources for SARS-CoV-2 viral sequences and genomic epidemiology. ArXiv. 2024; :. . PubMed PMID:38764594 PubMed Central PMC11100916.
  • Madi, N, Cato, ET, Abu Sayeed, M, Creasy-Marrazzo, A, Cuénod, A, Islam, K et al.. Phage predation, disease severity, and pathogen genetic diversity in cholera patients. Science. 2024;384 (6693):eadj3166. doi: 10.1126/science.adj3166. PubMed PMID:38669570 .
  • Batool, U, Tromas, N, Simon, DF, Sauvé, S, Shapiro, BJ, Ahmed, M et al.. Snapshot of cyanobacterial toxins in Pakistani freshwater bodies. Environ Sci Pollut Res Int. 2024;31 (16):24648-24661. doi: 10.1007/s11356-024-32744-w. PubMed PMID:38448773 .
  • Lypaczewski, P, Chac, D, Dunmire, CN, Tandoc, KM, Chowdhury, F, Khan, AI et al.. Diversity of Vibrio cholerae O1 through the human gastrointestinal tract during cholera. bioRxiv. 2024; :. doi: 10.1101/2024.02.08.579476. PubMed PMID:38370713 PubMed Central PMC10871328.
  • Douglas, GM, Shapiro, BJ. Pseudogenes act as a neutral reference for detecting selection in prokaryotic pangenomes. Nat Ecol Evol. 2024;8 (2):304-314. doi: 10.1038/s41559-023-02268-6. PubMed PMID:38177690 .
  • El Chaar, M, Khoury, Y, Douglas, GM, El Kazzi, S, Jisr, T, Soussi, S et al.. Longitudinal genomic surveillance of multidrug-resistant Escherichia coli carriage in critical care patients. Microbiol Spectr. 2024;12 (2):e0312823. doi: 10.1128/spectrum.03128-23. PubMed PMID:38171007 PubMed Central PMC10846182.
  • N'Guessan, A, Kailasam, S, Mostefai, F, Poujol, R, Grenier, JC, Ismailova, N et al.. Selection for immune evasion in SARS-CoV-2 revealed by high-resolution epitope mapping and sequence analysis. iScience. 2023;26 (8):107394. doi: 10.1016/j.isci.2023.107394. PubMed PMID:37599818 PubMed Central PMC10433132.
  • Madi, N, Cato, ET, Sayeed, MA, Creasy-Marrazzo, A, Cuénod, A, Islam, K et al.. Phage predation, disease severity and pathogen genetic diversity in cholera patients. bioRxiv. 2024; :. doi: 10.1101/2023.06.14.544933. PubMed PMID:37398242 PubMed Central PMC10312676.
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