Sirui Zhou
Assistant Professor, Department of Human Genetics
Email: sirui.zhou@mcgill.ca
Phone: (514) 398-8364
740 Dr Penfield Ave, Room 7101
Montréal, Québec, Canada, H3A 0G4
Sirui Zhou joined the Department of Human Genetics and the Canada Excellence Research Chair in Genomic Medicine as an assistant professor in January 2022. She obtained her PhD from the Université de Montréal in 2017, under the supervision of Dr. Guy Rouleau at the Neuro. Her PhD trainings were focused on the genetic architecture of Nunavik Inuit and intracranial aneurysms in founder populations of Quebec. Later, she pursued her studies in the lab of Dr. Brent Richards at the LDI, as a CIHR postdoctoral fellow. She leveraged multi-omics data and used genetic epidemiological methods to identify tractable biomarkers for osteoporosis, and during the pandemic, to identify potential drug targets for severe COVID-19.
Research Interests
Blood proteins can reflect the biological processes in tissues and thus are the first indicators of disease. They could be directly targeted for therapeutic intervention if the causal relationship between proteins and diseases are elucidated. Environmental and genetic factors associated with different ancestries may also reflect the change in proteomics and interactions between different omics, which could be leveraged to identify targets for disease. Currently, I am interested in using the proteomic, metabolomic and genomic data from the BQC19 (Banque québécoise de la COVID-19) and other large biobanks to explore potential targets that contribute to the risks to severe SARS-CoV2 infection and other related traits in multiple populations
Recent Publications
- Zhou, SR, Li, WG, Yang, LD, Xiang, H, Jin, Y, Feng, JB et al.. PTGS2 Silencing Inhibits Ferroptosis in Staphylococcus Aureus-induced Osteomyelitis By Blocking the IL-17A Signaling Pathway. Inflammation. 2025; :. doi: 10.1007/s10753-025-02296-3. PubMed PMID:40257651 .
- Shen, J, Chen, Y, Pan, M, Zhou, S, Xu, Y, Liu, F et al.. Rhizoma Drynariae-derived EV-like particles alleviate osteoporosis by promoting osteogenic differentiation in BMSCs through the activation of the hsa_circ_0001275/miR-422a pathway. Bone. 2025;196 :117489. doi: 10.1016/j.bone.2025.117489. PubMed PMID:40239729 .
- Xu, Z, Zhu, W, Zhou, S, Zhao, Y, Xiang, Q, Zhang, Y et al.. Corrigendum: Aspergillus fumigatus spondylitis in an immunocompetent patient with annular high signal around the intervertebral disks: a case report and literature review. Front Med (Lausanne). 2025;12 :1593828. doi: 10.3389/fmed.2025.1593828. PubMed PMID:40206481 PubMed Central PMC11978663.
- Luo, T, Wang, L, Zhang, L, Hu, MJ, Zhou, SR, He, XY et al.. Acute retinal necrosis following cataract surgery: a case of VZV reactivation and successful management. BMC Ophthalmol. 2025;25 (1):131. doi: 10.1186/s12886-025-03950-y. PubMed PMID:40087671 PubMed Central PMC11907935.
- Xu, M, Zhou, SR, Li, YL, Zhang, CH, Liao, DZ, Wang, XL et al.. Efficacy of sorafenib combined with transarterial chemoembolization in the treatment of advanced hepatocellular carcinoma: A meta-analysis. World J Gastrointest Oncol. 2025;17 (2):98927. doi: 10.4251/wjgo.v17.i2.98927. PubMed PMID:39958535 PubMed Central PMC11756001.
- Zhou, S, Han, X, Shi, Z, Zhang, Q, Cox, J, Pak, V et al.. Aminoacetone is associated with sleep latency. Sleep Med. 2025;128 :183-186. doi: 10.1016/j.sleep.2025.02.006. PubMed PMID:39954376 .
- Zhu, W, Yang, Z, Zhou, S, Zhang, J, Xu, Z, Xiong, W et al.. Modic changes: From potential molecular mechanisms to future research directions (Review). Mol Med Rep. 2025;31 (4):. doi: 10.3892/mmr.2025.13455. PubMed PMID:39918002 PubMed Central PMC11836598.
- Xu, Z, Zhu, W, Zhou, S, Zhao, Y, Xiang, Q, Zhang, Y et al.. Aspergillus fumigatus spondylitis in an immunocompetent patient with annular high signal around the intervertebral disks: a case report and literature review. Front Med (Lausanne). 2024;11 :1532282. doi: 10.3389/fmed.2024.1532282. PubMed PMID:39871834 PubMed Central PMC11771204.
- Yoshiji, S, Lu, T, Butler-Laporte, G, Carrasco-Zanini-Sanchez, J, Su, CY, Chen, Y et al.. Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease. Nat Genet. 2025;57 (2):345-357. doi: 10.1038/s41588-024-02052-7. PubMed PMID:39856218 PubMed Central PMC11821532.
- Yang, W, Pan, Q, Li, Q, Zhou, S, Cao, X. A simple, reliable and easily generalizable cell-based assay for screening potential drugs that inhibit lipid accumulation. Curr Res Toxicol. 2025;8 :100213. doi: 10.1016/j.crtox.2024.100213. PubMed PMID:39834517 PubMed Central PMC11743863.