Sirui Zhou
Assistant Professor, Department of Human Genetics
Email: sirui.zhou@mcgill.ca
Phone: (514) 398-8364
740 Dr Penfield Ave, Room 7101
Montréal, Québec, Canada, H3A 0G4
Sirui Zhou joined the Department of Human Genetics and the Canada Excellence Research Chair in Genomic Medicine as an assistant professor in January 2022. She obtained her PhD from the Université de Montréal in 2017, under the supervision of Dr. Guy Rouleau at the Neuro. Her PhD trainings were focused on the genetic architecture of Nunavik Inuit and intracranial aneurysms in founder populations of Quebec. Later, she pursued her studies in the lab of Dr. Brent Richards at the LDI, as a CIHR postdoctoral fellow. She leveraged multi-omics data and used genetic epidemiological methods to identify tractable biomarkers for osteoporosis, and during the pandemic, to identify potential drug targets for severe COVID-19.
Research Interests
Blood proteins can reflect the biological processes in tissues and thus are the first indicators of disease. They could be directly targeted for therapeutic intervention if the causal relationship between proteins and diseases are elucidated. Environmental and genetic factors associated with different ancestries may also reflect the change in proteomics and interactions between different omics, which could be leveraged to identify targets for disease. Currently, I am interested in using the proteomic, metabolomic and genomic data from the BQC19 (Banque québécoise de la COVID-19) and other large biobanks to explore potential targets that contribute to the risks to severe SARS-CoV2 infection and other related traits in multiple populations
Recent Publications
- Li, Q, Han, XC, Zhou, SR, Lu, Y, Wang, YJ, Yang, JK et al.. Discovery of novel cathepsin K inhibitors for osteoporosis treatment using a deep learning-based strategy. Expert Opin Drug Discov. 2025; :1-12. doi: 10.1080/17460441.2025.2527686. PubMed PMID:40600916 .
- Tan, X, Gao, B, Xu, Y, Zhao, Q, Jiang, J, Sun, D et al.. Atractylodes macrocephala-derived extracellular vesicles-like particles enhance the recovery of ulcerative colitis by remodeling intestinal microecological balance. J Nanobiotechnology. 2025;23 (1):433. doi: 10.1186/s12951-025-03506-8. PubMed PMID:40490795 PubMed Central PMC12150547.
- Xu, Z, Zhu, W, Zhou, S, Yang, Z, Xiang, L, Zhang, J et al.. Diagnostic imaging confusion in infectious spondylitis. J Orthop Surg Res. 2025;20 (1):496. doi: 10.1186/s13018-025-05781-5. PubMed PMID:40399964 PubMed Central PMC12096627.
- Sun, J, Zhou, S, Sun, Y, Zeng, Y. The clinical significance and potential therapeutic target of tumor-associated macrophage in non-small cell lung cancer. Front Med (Lausanne). 2025;12 :1541104. doi: 10.3389/fmed.2025.1541104. PubMed PMID:40370720 PubMed Central PMC12076932.
- Yang, Z, Zhou, S, Yang, Z, Liu, P, Chen, S, Zhu, W et al.. Metagenomic next-generation sequencing enabled diagnosis of Aspergillus spondylitis in an immunocompetent patient: a case report and literature review. Front Med (Lausanne). 2025;12 :1575363. doi: 10.3389/fmed.2025.1575363. PubMed PMID:40370716 PubMed Central PMC12074920.
- Liu, X, Cai, J, Zhou, S. Letter to the editor regarding "predictive value of post-operative neutrophil/lymphocyte count ratio for surgical site infection in patients following posterior lumbar spinal surgery". Int Immunopharmacol. 2025;157 :114747. doi: 10.1016/j.intimp.2025.114747. PubMed PMID:40328615 .
- Zhou, SR, Li, WG, Yang, LD, Xiang, H, Jin, Y, Feng, JB et al.. PTGS2 Silencing Inhibits Ferroptosis in Staphylococcus Aureus-induced Osteomyelitis By Blocking the IL-17A Signaling Pathway. Inflammation. 2025; :. doi: 10.1007/s10753-025-02296-3. PubMed PMID:40257651 .
- Shen, J, Chen, Y, Pan, M, Zhou, S, Xu, Y, Liu, F et al.. Rhizoma Drynariae-derived EV-like particles alleviate osteoporosis by promoting osteogenic differentiation in BMSCs through the activation of the hsa_circ_0001275/miR-422a pathway. Bone. 2025;196 :117489. doi: 10.1016/j.bone.2025.117489. PubMed PMID:40239729 .
- Xu, Z, Zhu, W, Zhou, S, Zhao, Y, Xiang, Q, Zhang, Y et al.. Corrigendum: Aspergillus fumigatus spondylitis in an immunocompetent patient with annular high signal around the intervertebral disks: a case report and literature review. Front Med (Lausanne). 2025;12 :1593828. doi: 10.3389/fmed.2025.1593828. PubMed PMID:40206481 PubMed Central PMC11978663.
- Luo, T, Wang, L, Zhang, L, Hu, MJ, Zhou, SR, He, XY et al.. Acute retinal necrosis following cataract surgery: a case of VZV reactivation and successful management. BMC Ophthalmol. 2025;25 (1):131. doi: 10.1186/s12886-025-03950-y. PubMed PMID:40087671 PubMed Central PMC11907935.