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Sirui Zhou

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Sirui Zhou

Assistant Professor, Department of Human Genetics

Email: sirui.zhou@mcgill.ca
Phone: (514) 398-8364

740 Dr Penfield Ave, Room 7101
Montréal, Québec, Canada, H3A 0G4

Sirui Zhou joined the Department of Human Genetics and the Canada Excellence Research Chair in Genomic Medicine as an assistant professor in January 2022. She obtained her PhD from the Université de Montréal in 2017, under the supervision of Dr. Guy Rouleau at the Neuro. Her PhD trainings were focused on the genetic architecture of Nunavik Inuit and intracranial aneurysms in founder populations of Quebec. Later, she pursued her studies in the lab of Dr. Brent Richards at the LDI, as a CIHR postdoctoral fellow. She leveraged multi-omics data and used genetic epidemiological methods to identify tractable biomarkers for osteoporosis, and during the pandemic, to identify potential drug targets for severe COVID-19. 

Research Interests

Blood proteins can reflect the biological processes in tissues and thus are the first indicators of disease. They could be directly targeted for therapeutic intervention if the causal relationship between proteins and diseases are elucidated. Environmental and genetic factors associated with different ancestries may also reflect the change in proteomics and interactions between different omics, which could be leveraged to identify targets for disease. Currently, I am interested in using the proteomic, metabolomic and genomic data from the BQC19 (Banque québécoise de la COVID-19) and other large biobanks to explore potential targets that contribute to the risks to severe SARS-CoV2 infection and other related traits in multiple populations

Recent Publications

  • Sun, J, Rao, L, Zhou, S, Zeng, Y, Sun, Y. Unraveling the regulatory cell death pathways in gastric cancer: a multi-omics study. Front Pharmacol. 2024;15 :1447970. doi: 10.3389/fphar.2024.1447970. PubMed PMID:39314752 PubMed Central PMC11417042.
  • Zhu, Y, Li, T, Zhou, S, Wang, G, Zhang, H, Yin, Y et al.. Survivin inhibition attenuates EGF-induced epithelial mesenchymal transformation of human RPE cells via the EGFR/MAPK pathway. PLoS One. 2024;19 (8):e0309539. doi: 10.1371/journal.pone.0309539. PubMed PMID:39213375 PubMed Central PMC11364297.
  • Zhu, W, Zhou, S, Xu, Z, Yang, Z, Zhang, J. Melampsora spondylitis presenting with unexplained low back pain: A case report. Int J Infect Dis. 2024;148 :107225. doi: 10.1016/j.ijid.2024.107225. PubMed PMID:39197743 .
  • Yuan, YC, Wang, H, Jiang, ZJ, Liu, C, Li, Q, Zhou, SR et al.. Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies. Signal Transduct Target Ther. 2024;9 (1):207. doi: 10.1038/s41392-024-01923-z. PubMed PMID:39128897 PubMed Central PMC11317495.
  • Li, Q, Zhou, SR, Kim, H, Wang, H, Zhu, JJ, Yang, JK et al.. Discovering novel Cathepsin L inhibitors from natural products using artificial intelligence. Comput Struct Biotechnol J. 2024;23 :2606-2614. doi: 10.1016/j.csbj.2024.06.009. PubMed PMID:39006920 PubMed Central PMC11245987.
  • Zhu, YS, Zhou, SR, Zhang, HH, Wang, T, Chen, XD. Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway. Int J Ophthalmol. 2024;17 (6):1018-1027. doi: 10.18240/ijo.2024.06.05. PubMed PMID:38895677 PubMed Central PMC11144774.
  • Ilboudo, Y, Yoshiji, S, Lu, T, Butler-Laporte, G, Zhou, S, Richards, JB et al.. Vitamin D, Cognition, and Alzheimer's Disease: Observational and Two-Sample Mendelian Randomization Studies. J Alzheimers Dis. 2024;99 (4):1243-1260. doi: 10.3233/JAD-221223. PubMed PMID:38820015 .
  • Zhou, S, Zhu, W, Guo, H, Nie, Y, Sun, J, Liu, P et al.. Microbes for lung cancer detection: feasibility and limitations. Front Oncol. 2024;14 :1361879. doi: 10.3389/fonc.2024.1361879. PubMed PMID:38779090 PubMed Central PMC11109454.
  • Sun, J, Guo, H, Zhang, S, Nie, Y, Zhou, S, Zeng, Y et al.. Machine learning-based integration develops an immunogenic cell death-derived lncRNA signature for predicting prognosis and immunotherapy response in lung adenocarcinoma. Sci Rep. 2024;14 (1):11724. doi: 10.1038/s41598-024-62569-z. PubMed PMID:38778157 PubMed Central PMC11111459.
  • Zhou, SR, Zhu, YS, Yuan, WT, Pan, XY, Wang, T, Chen, XD et al.. Hepatocyte growth factor promotes retinal pigment epithelium cell activity through MET/AKT signaling pathway. Int J Ophthalmol. 2024;17 (5):806-814. doi: 10.18240/ijo.2024.05.03. PubMed PMID:38766346 PubMed Central PMC11074208.
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