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Elin Grundberg

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Elin Grundberg

Adjunct Professor, Department of Human Genetics

Email: egrundberg@cmh.edu
Phone: (NNN) NNN-NNNN

Children’s Mercy Hospital
2401 Gillham Rd
Kansas City MO 64108

Dr. Elin Grundberg completed her PhD (2006) in Molecular Medicine at Uppsala University, Sweden and following post-doctoral training at the McGill University and Genome Quebec Innovation Centre she joined Wellcome Trust Sanger institute in 2009 to lead the international MuTHER Consortium, which included developing a major resource of detailed genomics and epigenomics data from multiple disease-targeted tissues from twins. In 2012, she was appointed Tenure-Track Assistant Professor at the Department of Human Genetics at McGill University where her group was applying various next-generation sequencing approaches to understand genetic and epigenetic factors underlying complex disease susceptibility. Dr. Grundberg lead two CIHR team grants on this topic including the EpiTriO Consotium with partners in Canada and Europe. She held a Canada Research Chair (tier 2) in Disease Genomics and Epigenomics. 

In Oct 2017, Dr. Grundberg joined the faculty at Children’s Mercy Kansas City where she holds the Roberta D. Harding & William F. Bradley, Jr. Endowed Chair in Genomic Research. She is building a comprehensive research program leveraging international collaborations (King’s College London, UK; INSERM, France, Helmholtz Zentrum, Germany, McGill, Canada) as well as local collaborators (CM, UMKC, KUMC) for tissue-resources and methodologies essential for contemporary disease genomics and epigenomics. Research areas span genomics medicine applied in pediatric and adult populations including rare diseases, metabolic diseases, social and environmental health and perinatal/maternal health.

Dr. Grundberg currently collaborates with a number of large international research consortia and is the author of over 75 scientific papers.

Recent Publications

  • Pastinen, T, Grundberg, E, Bradley, T, Honkanen, J, Cheung, W, Vuorela, A et al.. Evolving epigenomics of immune cells in type 1 diabetes at single nuclei resolution. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-5588592/v1. PubMed PMID:40195977 PubMed Central PMC11975021.
  • Spector, BL, Koseva, B, McLennan, R, Banerjee, D, Lankachandra, K, Bradley, T et al.. Methylation patterns of the nasal epigenome of hospitalized SARS-CoV-2 positive patients reveal insights into molecular mechanisms of COVID-19. BMC Med Genomics. 2025;18 (1):62. doi: 10.1186/s12920-025-02125-4. PubMed PMID:40170038 PubMed Central PMC11963311.
  • Spector, BL, Koseva, BS, Sante, D, Cheung, WA, Alisch, RS, Kats, A et al.. Total plasma cfDNA methylation in pediatric kidney transplant recipients provides insight into acute allograft rejection pathophysiology. Clin Immunol. 2025;275 :110475. doi: 10.1016/j.clim.2025.110475. PubMed PMID:40107586 .
  • Berrios, C, Basey, T, Bradley-Ewing, A, Daniels-Young, S, Lewis, D, Feldman, K et al.. Black community member perceptions and ethics recommendations on epigenomic research. Clin Epigenetics. 2025;17 (1):33. doi: 10.1186/s13148-025-01840-0. PubMed PMID:39987106 PubMed Central PMC11847333.
  • Smail, C, Ge, B, Keever-Keigher, MR, Schwendinger-Schreck, C, Cheung, WA, Johnston, JJ et al.. Complex trait associations in rare diseases and impacts on Mendelian variant interpretation. Nat Commun. 2024;15 (1):8196. doi: 10.1038/s41467-024-52407-1. PubMed PMID:39294130 PubMed Central PMC11411080.
  • Keever-Keigher, MR, Harvey, L, Williams, V, Vyhlidal, CA, Ahmed, AA, Johnston, JJ et al.. Genomic insights into pediatric intestinal inflammatory and eosinophilic disorders using single-cell RNA-sequencing. Front Immunol. 2024;15 :1420208. doi: 10.3389/fimmu.2024.1420208. PubMed PMID:39192974 PubMed Central PMC11347318.
  • Feldman, K, Kane, NJ, Daniels-Young, S, Reed, B, Welch, J, Fitzpatrick, L et al.. Utilization of geospatial distribution in the measurement of study cohort representativeness. J Biomed Inform. 2024;157 :104687. doi: 10.1016/j.jbi.2024.104687. PubMed PMID:38986921 PubMed Central PMC11402570.
  • Mann, LK, Pandiri, S, Agarwal, N, Northrup, H, Au, KS, Grundberg, E et al.. Morphometric Analysis of Spina Bifida after Fetal Repair Shows New Subtypes with Associated Outcomes. medRxiv. 2024; :. doi: 10.1101/2024.05.29.24308088. PubMed PMID:38853851 PubMed Central PMC11160825.
  • Christiansen, C, Potier, L, Martin, TC, Villicaña, S, Castillo-Fernandez, JE, Mangino, M et al.. Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications. EBioMedicine. 2024;103 :105096. doi: 10.1016/j.ebiom.2024.105096. PubMed PMID:38574408 PubMed Central PMC11004697.
  • Smail, C, Ge, B, Keever-Keigher, MR, Schwendinger-Schreck, C, Cheung, W, Johnston, JJ et al.. Complex trait associations in rare diseases and impacts on Mendelian variant interpretation. medRxiv. 2024; :. doi: 10.1101/2024.01.10.24301111. PubMed PMID:38260377 PubMed Central PMC10802745.
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