Elin Grundberg

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Elin Grundberg

Adjunct Professor, Department of Human Genetics

Email: egrundberg@cmh.edu

Children’s Mercy Hospital
2401 Gillham Rd
Kansas City MO 64108

Dr. Elin Grundberg completed her PhD (2006) in Molecular Medicine at Uppsala University, Sweden and following post-doctoral training at the McGill University and Genome Quebec Innovation Centre she joined Wellcome Trust Sanger institute in 2009 to lead the international MuTHER Consortium, which included developing a major resource of detailed genomics and epigenomics data from multiple disease-targeted tissues from twins. In 2012, she was appointed Tenure-Track Assistant Professor at the Department of Human Genetics at McGill University where her group was applying various next-generation sequencing approaches to understand genetic and epigenetic factors underlying complex disease susceptibility. Dr. Grundberg lead two CIHR team grants on this topic including the EpiTriO Consotium with partners in Canada and Europe. She held a Canada Research Chair (tier 2) in Disease Genomics and Epigenomics. 

In Oct 2017, Dr. Grundberg joined the faculty at Children’s Mercy Kansas City where she holds the Roberta D. Harding & William F. Bradley, Jr. Endowed Chair in Genomic Research. She is building a comprehensive research program leveraging international collaborations (King’s College London, UK; INSERM, France, Helmholtz Zentrum, Germany, McGill, Canada) as well as local collaborators (CM, UMKC, KUMC) for tissue-resources and methodologies essential for contemporary disease genomics and epigenomics. Research areas span genomics medicine applied in pediatric and adult populations including rare diseases, metabolic diseases, social and environmental health and perinatal/maternal health.

Dr. Grundberg currently collaborates with a number of large international research consortia and is the author of over 75 scientific papers.

Recent Publications

  • Fraley, E, LeMaster, C, Khanal, S, Banerjee, D, Pastinen, T, Grundberg, E et al.. Prior infection and age impacts antibody persistence after SARS-CoV-2 mRNA vaccine. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab850. PubMed PMID:34551091 PubMed Central PMC8522412.
  • Winkley, K, Banerjee, D, Bradley, T, Koseva, B, Cheung, WA, Selvarangan, R et al.. Immune cell residency in the nasal mucosa may partially explain respiratory disease severity across the age range. Sci Rep. 2021;11 (1):15927. doi: 10.1038/s41598-021-95532-3. PubMed PMID:34354210 PubMed Central PMC8342554.
  • Fraley, E, LeMaster, C, Geanes, E, Banerjee, D, Khanal, S, Grundberg, E et al.. Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individuals. BMC Med. 2021;19 (1):169. doi: 10.1186/s12916-021-02055-9. PubMed PMID:34304742 PubMed Central PMC8310732.
  • Winkley, K, Koseva, B, Banerjee, D, Cheung, W, Selvarangan, R, Pastinen, T et al.. High-resolution epigenome analysis in nasal samples derived from children with respiratory viral infections reveals striking changes upon SARS-CoV-2 infection. medRxiv. 2021; :. doi: 10.1101/2021.03.09.21253155. PubMed PMID:33758880 PubMed Central PMC7987039.
  • Bradley, T, Grundberg, E, Selvarangan, R, LeMaster, C, Fraley, E, Banerjee, D et al.. Antibody Responses after a Single Dose of SARS-CoV-2 mRNA Vaccine. N Engl J Med. 2021;384 (20):1959-1961. doi: 10.1056/NEJMc2102051. PubMed PMID:33755375 PubMed Central PMC8008753.
  • Ostinelli, G, Vijay, J, Vohl, MC, Grundberg, E, Tchernof, A. AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants. Mol Cell Endocrinol. 2021;527 :111220. doi: 10.1016/j.mce.2021.111220. PubMed PMID:33675863 PubMed Central PMC8052191.
  • Varberg, KM, Iqbal, K, Muto, M, Simon, ME, Scott, RL, Kozai, K et al.. ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proc Natl Acad Sci U S A. 2021;118 (10):. doi: 10.1073/pnas.2016517118. PubMed PMID:33649217 PubMed Central PMC7958375.
  • Bradley, T, Grundberg, E, Selvarangan, R. Antibody responses boosted in seropositive healthcare workers after single dose of SARS-CoV-2 mRNA vaccine. medRxiv. 2021; :. doi: 10.1101/2021.02.03.21251078. PubMed PMID:33564797 PubMed Central PMC7872392.
  • Allum, F, Grundberg, E. Capturing functional epigenomes for insight into metabolic diseases. Mol Metab. 2020;38 :100936. doi: 10.1016/j.molmet.2019.12.016. PubMed PMID:32199819 PubMed Central PMC7300388.
  • Péan, N, Le Lay, A, Brial, F, Wasserscheid, J, Rouch, C, Vincent, M et al.. Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. Diabetologia. 2020;63 (6):1223-1235. doi: 10.1007/s00125-020-05122-7. PubMed PMID:32173762 PubMed Central PMC7228998.
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