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Jacek Majewski

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Jacek Majewski

Associate Professor, Department of Human Genetics

Email: jacek.majewski@mcgill.ca
Phone: (514) 398-3311 x00891

740 Dr Penfield Ave, Room 7210
Montréal, Québec, Canada, H3A 0G1

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Professor Jacek Majewski received a PhD in Evolutionary Biology from Wesleyan University (1999), a Master’s in Electrical Engineering from Stanford University (1991) and a Bachelor in Physics, also from Stanford (1990). He is Associate Professor, Department of Human Genetics, Faculty of Medicine at McGill University and holds the Canada Research Chair in Statistical Genetics. Prof. Majewski’s research is based on genomics and bioinformatics analysis of high throughput data. The recent revolution in massively parallel DNA sequencing has opened new venues into numerous biomedical problems.

My group specializes in the analysis of high throughput genomics data, with specific applications to human hereditary disease and cancer. My diverse background combining quantitative sciences and biology has become a strong asset in the era of big data in biology. I have a long history of leading projects both as a PI and collaborations in large teams. My participation in collaborative teams resulted in over 200 publications utilizing high throughput sequencing approaches in genetics of disease, cancer, and basic biology My current interests focus on the role of epigenetic dysregulation in cancer. In order to better understand disease states, we have also ventured into exploring the balance of chromatin modification during normally progressing development. As the next frontier, we are also working on integrating classical epigenetic approaches with chromatin conformation data and developing methods to visualize and analyzed chromatin in a three dimensional framework.

Recent Publications

  • Oussalah, A, Siblini, Y, Hergalant, S, Chéry, C, Rouyer, P, Cavicchi, C et al.. Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12. Clin Epigenetics. 2022;14 (1):52. doi: 10.1186/s13148-022-01271-1. PubMed PMID:35440018 PubMed Central PMC9020039.
  • Chen, H, Hu, B, Horth, C, Bareke, E, Rosenbaum, P, Kwon, SY et al.. H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells. Genome Res. 2022;32 (5):825-837. doi: 10.1101/gr.276383.121. PubMed PMID:35396277 .
  • Biondini, M, Kiepas, A, El-Houjeiri, L, Annis, MG, Hsu, BE, Fortier, AM et al.. HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin. Oncogene. 2022;41 (12):1701-1717. doi: 10.1038/s41388-022-02206-z. PubMed PMID:35110681 .
  • Fierheller, CT, Guitton-Sert, L, Alenezi, WM, Revil, T, Oros, KK, Gao, Y et al.. A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene. Genome Med. 2021;13 (1):186. doi: 10.1186/s13073-021-00998-5. PubMed PMID:34861889 PubMed Central PMC8642877.
  • Yokobayashi, S, Yabuta, Y, Nakagawa, M, Okita, K, Hu, B, Murase, Y et al.. Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells. Cell Rep. 2021;37 (5):109909. doi: 10.1016/j.celrep.2021.109909. PubMed PMID:34731633 .
  • Rezaei, M, Buckett, W, Bareke, E, Surti, U, Majewski, J, Slim, R et al.. A protein-truncating mutation in CCNB3 in a patient with recurrent miscarriages and failure of meiosis I. J Med Genet. 2022;59 (6):568-570. doi: 10.1136/jmedgenet-2021-107875. PubMed PMID:34021051 .
  • Weinberg, DN, Rosenbaum, P, Chen, X, Barrows, D, Horth, C, Marunde, MR et al.. Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands. Nat Genet. 2021;53 (6):794-800. doi: 10.1038/s41588-021-00856-5. PubMed PMID:33986537 PubMed Central PMC8283687.
  • Farhangdoost, N, Horth, C, Hu, B, Bareke, E, Chen, X, Li, Y et al.. Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma. Cell Rep. 2021;34 (8):108769. doi: 10.1016/j.celrep.2021.108769. PubMed PMID:33626351 PubMed Central PMC8006058.
  • Rajagopalan, KN, Chen, X, Weinberg, DN, Chen, H, Majewski, J, Allis, CD et al.. Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation. Proc Natl Acad Sci U S A. 2021;118 (9):. doi: 10.1073/pnas.2021795118. PubMed PMID:33619101 PubMed Central PMC7936350.
  • Beauchamp, MC, Djedid, A, Bareke, E, Merkuri, F, Aber, R, Tam, AS et al.. Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53. Hum Mol Genet. 2021;30 (9):739-757. doi: 10.1093/hmg/ddab051. PubMed PMID:33601405 PubMed Central PMC8161524.
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