Guillaume Bourque

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Guillaume Bourque

Professor, Department of Human Genetics

Email: guil.bourque@mcgill.ca
Phone: (514) 398-8602
Fax: (514) 398-1790

740 Dr Penfield Ave, Room 6103
Montréal, Québec, Canada, H3A 1A4


Dr. Bourque joined McGill University in 2010 and is a Professor in the Department of Human Genetics and the Director of Bioinformatics at the McGill Genome Center. During his PhD, he worked on genome rearrangements in evolution with Pavel Pevzner at the University of Southern California. From 2004 to 2010, he worked at the Genome Institute of Singapore, where he was a Senior Group Leader and the Associate Director of Computational & Mathematical Biology. Dr. Bourque leads the Canadian Center for Computational Genomics (C3G), a Genome Canada bioinformatics platform, and the McGill initiative in Computational Medicine (MiCM). He is also the head of the Epigenomics Mapping Center at McGill, a project that oversees data generation and processing as part of the Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC), which is associated with the International Human Epigenome Consortium (IHEC). He is also the chair of the Integrative Analysis working group of IHEC.

Dr. Bourque is a member of the Advisory Board of CIHR’s Institute of Genetics and is on the External Consultant Panel of the US-funded Encyclopedia of DNA Elements (ENCODE) project. He is also on the Steering Committee of the Global Alliance for Genomics and Health (GA4GH) since two of his projects, CanDIG and EpiShare, have been selected as Driver Projects by the organization. Dr. Bourque is also on the Research Advisory Council of Compute Canada, the national platform for high-performance computing, and of CANARIE, responsible for Canada’s ultra-fast network backbone. In 2019, his leadership in Digital Research Infrastructure was recognized and he was named as one of the 4 Directors of the Applicant Board of the new organization that will coordinate these efforts for Canada. This new organization is funded by the Ministry of Innovation, Science and Economic Development Canada (ISED), with a budget of 375 M$ over the next 5 years, to deploy and coordinate a national infrastructure (covering high-performance computing, software and data management) that will support all areas of research.

Research Interests

The goal of the Bourque lab is to understand mammalian genomes using comparative genomic and epigenomic analyses. Areas of interest include: the evolution of regulatory sequences, the role of transposable elements in gene regulation and the impact of genome rearrangements in evolution and cancer. Work in the lab involves examining the billions of DNA base pairs and interpreting how variation impacts basic biology and disease. One objective is to develop computational methods and resources for the functional annotation of genomes with a special emphasis on sequencing-based assays (e.g. ChIP-seq, RNA-Seq, exome- and whole-genome sequencing, single-cell analysis). Dr. Bourque is also in an ideal position to contribute and drive large health initiatives that have a strong genomic and bioinformatics component. His lab develops advanced tools and scalable computational infrastructure to enable large-scale applied research projects.

Recent Publications

  • Mendel, A, Colmegna, I, Bourque, G, Rajda, E, Lee, TC, Gálvez, JH et al.. More than a 'Hundred Days War': Persistent SARS-CoV-2 infection in a patient with ANCA-associated vasculitis. J Assoc Med Microbiol Infect Dis Can. 2022;7 (2):131-134. doi: 10.3138/jammi-2021-0033. PubMed PMID:36337358 PubMed Central PMC9608116.
  • Butler-Laporte, G, Povysil, G, Kosmicki, JA, Cirulli, ET, Drivas, T, Furini, S et al.. Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative. PLoS Genet. 2022;18 (11):e1010367. doi: 10.1371/journal.pgen.1010367. PubMed PMID:36327219 PubMed Central PMC9632827.
  • Farooq, Z, Kusuma, F, Burke, P, Dufour, CR, Lee, D, Tabatabaei, N et al.. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1). J Biol Chem. 2022;298 (9):102277. doi: 10.1016/j.jbc.2022.102277. PubMed PMID:35863436 PubMed Central PMC9396407.
  • Olson, ND, Wagner, J, McDaniel, J, Stephens, SH, Westreich, ST, Prasanna, AG et al.. PrecisionFDA Truth Challenge V2: Calling variants from short and long reads in difficult-to-map regions. Cell Genom. 2022;2 (5):. doi: 10.1016/j.xgen.2022.100129. PubMed PMID:35720974 PubMed Central PMC9205427.
  • Fava, VM, Bourgey, M, Nawarathna, PM, Orlova, M, Cassart, P, Vinh, DC et al.. A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19. Sci Adv. 2022;8 (22):eabm2510. doi: 10.1126/sciadv.abm2510. PubMed PMID:35648852 PubMed Central PMC9159580.
  • Golesworthy, B, Wang, Y, Tanti, A, Pacis, A, Romero, JM, Cuggia, A et al.. Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma. Front Oncol. 2022;12 :860767. doi: 10.3389/fonc.2022.860767. PubMed PMID:35547873 PubMed Central PMC9082359.
  • Couturier, CP, Nadaf, J, Li, Z, Baig, S, Riva, G, Le, P et al.. Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells. Neuro Oncol. 2022;24 (9):1494-1508. doi: 10.1093/neuonc/noac085. PubMed PMID:35416251 PubMed Central PMC9435507.
  • Sahinyan, K, Blackburn, DM, Simon, MM, Lazure, F, Kwan, T, Bourque, G et al.. Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution. Elife. 2022;11 :. doi: 10.7554/eLife.72792. PubMed PMID:35188098 PubMed Central PMC8901173.
  • Rehm, HL, Page, AJH, Smith, L, Adams, JB, Alterovitz, G, Babb, LJ et al.. GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genom. 2021;1 (2):. doi: 10.1016/j.xgen.2021.100029. PubMed PMID:35072136 PubMed Central PMC8774288.
  • Breeze, CE, Haugen, E, Reynolds, A, Teschendorff, A, van Dongen, J, Lan, Q et al.. Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations. Genome Biol. 2022;23 (1):13. doi: 10.1186/s13059-021-02560-3. PubMed PMID:34996498 PubMed Central PMC8742386.
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