Genotyping Microarray Platform
“Genotyping is still unmatched when it comes to scale and reproducibility. For large cohorts and population studies, it’s the workhorse - especially when you need reliable data across tens of thousands of samples.” - Ioannis Ragoussis (Head of Genome Sciences)
Array-based technologies provide a scalable, cost-effective means of interrogating the genome and epigenome across large cohorts. At the McGill Genome Centre our Microarray platform supports high-throughput genotyping and DNA methylation analysis, enabling robust variant detection and epigenetic profiling. Closely aligned with sequencing technologies, these approaches underpin genome-wide association studies (GWAS), population genetics, pharmacogenomics, and investigations into disease-related epigenetic changes. While sequencing offers base-level resolution, array-based methods excel in screening, cohort stratification, and hypothesis-driven variant detection.
We offer standardized and customizable array-based genotyping services, using SNP and methylation platforms. With integrated project management and downstream bioinformatics support, our services help researchers quickly generate reproducible, high-quality data across a range of study designs.
Common Applications
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Large-scale variant discovery for GWAS, population studies, and disease association.
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Focused analysis of known variants for validation, screening, or allele frequency estimation.
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High-resolution epigenetic profiling for cancer, developmental biology, and aging studies.
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Flexible genotyping designs for species-specific or trait-focused studies in genetics and agriculture.
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Variant detection in drug metabolism genes to inform treatment selection and patient stratification.
Microarray Technologies at MGC
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High-density SNP genotyping for GWAS and large cohort studies.
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Supports SNP and DNA methylation arrays (e.g., Infinium, EPIC), with broad coverage and flexibility.
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Widely used for genome-wide SNP detection and population genetics.
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Genome-wide methylation profiling for epigenetics and disease-related studies.
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Targeted and customizable SNP genotyping for screening and marker-assisted selection.
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Cost-effective validation of known variants with high specificity.
"Through the rapid deployment of array-based genotyping and timely data sharing via the COVID-19 Host Genetics Initiative, we were able to generate critical genomic insights well in advance of whole genome sequencing results—underscoring the strategic value of array technologies when timely information is paramount."
Daniel Auld, Deputy Director and Head of Operations
Platform deliverables
Our genotyping services are supported by dedicated project managers and bioinformatics experts. We assist with array selection, custom panel design, and sample tracking, and provide downstream analysis and visualization. Bioinformatics support is delivered in collaboration with the Canadian Centre for Computational Genomics (C3G), ensuring reproducible data processing and compatibility with multi-omic integration.
Integrated Support and Data Analysis
Our genotyping services are supported by dedicated project managers and bioinformatics experts. We assist with array selection, custom panel design, and sample tracking, and provide downstream analysis and visualization. Bioinformatics support is delivered in collaboration with the Canadian Centre for Computational Genomics (C3G), ensuring reproducible data processing and compatibility with multi-omic integration.