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Dara Torgerson

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Dara Torgerson

Assistant Professor, Department of Human Genetics

Email:
Phone: (514) 398-7510

740 Dr Penfield Ave
Montréal, Québec, Canada, H3A 0G1

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We study genomics and metabolomics to increase our understanding of complex disease and response to interventions in diverse human populations. We develop bioinformatic and computational approaches for the analysis of multi-omics data in genetically structured and vulnerable populations for addressing clinically relevant hypotheses. We are highly collaborative and work in close partnership with physician scientists on clinical studies of human disease.

Research Interests

GENETIC STUDIES OF HUMAN DISEASE
Genetic association studies have identified novel genes and pathways involved in disease and furthered our understanding of differential response to therapies. My group develops computational strategies to accelerate discovery in genomic studies of human disease, with an emphasis on structured and diverse populations. Our current research in this area includes studies of asthma and bronchopulmonary dysplasia in preterm infants (BPD).

INTEGRATIVE METABOLOMICS AND PRECISION MEDICINE
A multi-disciplinary effort is required to advance precision medicine. We develop computational strategies for the analysis and integration of multi-omics data to accelerate biological discovery in clinical studies of complex disease in diverse populations. Our current research in this area includes the coupling of genomics and untargeted metabolomics to identify metabolite quantitative trait loci (mQTLs) that are relevant to postnatal lung development, drug response, and bronchopulmonary dysplasia in extremely preterm infants.

Recent Publications

  • Ijpma, G, Kachmar, L, Panariti, A, Matusovsky, OS, Torgerson, D, Benedetti, A et al.. Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma. Eur. Respir. J. 2020;56 (1):. doi: 10.1183/13993003.02178-2019. PubMed PMID:32299863 .
  • Vince, N, Limou, S, Daya, M, Morii, W, Rafaels, N, Geffard, E et al.. Association of HLA-DRB1∗09:01 with tIgE levels among African-ancestry individuals with asthma. J. Allergy Clin. Immunol. 2020;146 (1):147-155. doi: 10.1016/j.jaci.2020.01.011. PubMed PMID:31981624 .
  • Geffard, E, Limou, S, Walencik, A, Daya, M, Watson, H, Torgerson, D et al.. Easy-HLA: a validated web application suite to reveal the full details of HLA typing. Bioinformatics. 2020;36 (7):2157-2164. doi: 10.1093/bioinformatics/btz875. PubMed PMID:31750874 .
  • Calabrese, DR, Wang, P, Chong, T, Hoover, J, Singer, JP, Torgerson, D et al.. Dectin-1 genetic deficiency predicts chronic lung allograft dysfunction and death. JCI Insight. 2019;4 (22):. doi: 10.1172/jci.insight.133083. PubMed PMID:31613800 PubMed Central PMC6948872.
  • Daya, M, Rafaels, N, Brunetti, TM, Chavan, S, Levin, AM, Shetty, A et al.. Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019;10 (1):4082. doi: 10.1038/s41467-019-12158-w. PubMed PMID:31484942 PubMed Central PMC6726619.
  • Ley, B, Torgerson, DG, Oldham, JM, Adegunsoye, A, Liu, S, Li, J et al.. Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. Am. J. Respir. Crit. Care Med. 2019;200 (9):1154-1163. doi: 10.1164/rccm.201902-0360OC. PubMed PMID:31268371 PubMed Central PMC6888660.
  • Daya, M, Rafaels, N, Brunetti, TM, Chavan, S, Levin, AM, Shetty, A et al.. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019;10 (1):880. doi: 10.1038/s41467-019-08469-7. PubMed PMID:30787307 PubMed Central PMC6382865.
  • Lewis, T, Truog, W, Norberg, M, Ballard, PL, Torgerson, D, TOLSURF Study Group et al.. Correction: Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia. Pediatr. Res. 2019;85 (5):731. doi: 10.1038/s41390-019-0314-y. PubMed PMID:30733615 .
  • Lewis, T, Truog, W, Norberg, M, Ballard, PL, Torgerson, D, TOLSURF Study Group et al.. Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia. Pediatr. Res. 2019;85 (5):625-633. doi: 10.1038/s41390-018-0235-1. PubMed PMID:30467342 PubMed Central PMC6532775.
  • Spear, ML, Hu, D, Pino-Yanes, M, Huntsman, S, Eng, C, Levin, AM et al.. A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma. Pharmacogenomics J. 2019;19 (3):249-259. doi: 10.1038/s41397-018-0042-4. PubMed PMID:30206298 PubMed Central PMC6414286.
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