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Marc Dumas

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Marc Dumas

Professor, Department of Human Genetics

Email:
Phone: (514) 398-8602
Fax: (514) 398-1790

Website

Dr. Marc-Emmanuel Dumas is Adjunct Professor at McGill and Chair in Systems Medicine at Imperial College London. He develops novel research avenues in the field of metabolomics in systems medicine, targeting mostly metabolic and cardiorespiratory diseases but also chronic inflammation, brain health and cancer.  He studies the undermining biology leading to metabolic variations observed in these various contexts using genomics, metagenomics and cellular networks. Dr. Dumas has discovered that many microbial metabolites are bioactive and he focusses on identifying causality chains involving these metabolites as well as host targets they engage with.

Recent Publications

  • Brial, F, Chilloux, J, Nielsen, T, Vieira-Silva, S, Falony, G, Andrikopoulos, P et al.. Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut. 2021; :. doi: 10.1136/gutjnl-2020-323314. PubMed PMID:33975870 .
  • Mayneris-Perxachs, J, Cardellini, M, Hoyles, L, Latorre, J, Davato, F, Moreno-Navarrete, JM et al.. Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome. Microbiome. 2021;9 (1):104. doi: 10.1186/s40168-021-01052-7. PubMed PMID:33962692 PubMed Central PMC8106161.
  • Letertre, MPM, Myridakis, A, Whiley, L, Camuzeaux, S, Lewis, MR, Chappell, KE et al.. A targeted ultra performance liquid chromatography - Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1164 :122511. doi: 10.1016/j.jchromb.2020.122511. PubMed PMID:33460909 .
  • Molinaro, A, Bel Lassen, P, Henricsson, M, Wu, H, Adriouch, S, Belda, E et al.. Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nat Commun. 2020;11 (1):6448. doi: 10.1038/s41467-020-20412-9. PubMed PMID:33349634 PubMed Central PMC7752903.
  • Molinaro, A, Bel Lassen, P, Henricsson, M, Wu, H, Adriouch, S, Belda, E et al.. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. Nat Commun. 2020;11 (1):5881. doi: 10.1038/s41467-020-19589-w. PubMed PMID:33208748 PubMed Central PMC7676231.
  • Vieira-Silva, S, Falony, G, Belda, E, Nielsen, T, Aron-Wisnewsky, J, Chakaroun, R et al.. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature. 2020;581 (7808):310-315. doi: 10.1038/s41586-020-2269-x. PubMed PMID:32433607 .
  • Mayneris-Perxachs, J, Puig, J, Burcelin, R, Dumas, ME, Barton, RH, Hoyles, L et al.. The APOA1bp-SREBF-NOTCH axis is associated with reduced atherosclerosis risk in morbidly obese patients. Clin Nutr. 2020;39 (11):3408-3418. doi: 10.1016/j.clnu.2020.02.034. PubMed PMID:32199697 .
  • Péan, N, Le Lay, A, Brial, F, Wasserscheid, J, Rouch, C, Vincent, M et al.. Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling. Diabetologia. 2020;63 (6):1223-1235. doi: 10.1007/s00125-020-05122-7. PubMed PMID:32173762 PubMed Central PMC7228998.
  • Brial, F, Alzaid, F, Sonomura, K, Kamatani, Y, Meneyrol, K, Le Lay, A et al.. The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances β-Cell Function. Cell Rep. 2020;30 (7):2306-2320.e5. doi: 10.1016/j.celrep.2020.01.066. PubMed PMID:32075738 .
  • Abdul Rahim, MBH, Chilloux, J, Martinez-Gili, L, Neves, AL, Myridakis, A, Gooderham, N et al.. Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles. Acta Diabetol. 2019;56 (5):493-500. doi: 10.1007/s00592-019-01312-x. PubMed PMID:30903435 PubMed Central PMC6451719.
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